{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:22:47Z","timestamp":1753881767130,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To assess the efficacy of Erzhu Yiren Decoction in treating gastric ulcer of spleen deficiency and dampness\u2010heat and its effect on serum NO, EGF, and PGE2 levels. <jats:italic>Methods<\/jats:italic>. A retrospective study was conducted among 64 patients with gastric ulcers of spleen deficiency and dampness heat admitted to our hospital from September 2019 to May 2020, and they were divided at a ratio of 1\u2009:\u20091 into an observation group (rabeprazole sodium enteric\u2010coated capsules plus Erzhu Yiren Decoction) and a control group (rabeprazole sodium enteric\u2010coated capsules) based on different treatment methods. The clinical symptom scores, the effective rate of ulcer healing under gastroscopy, the quality of ulcer healing (QOUH), serum nitric oxide (NO), endothelial growth factor (EGF), and prostaglandin E2 (PGE2) levels were compared between the two groups. <jats:italic>Results<\/jats:italic>. The clinical symptom scores of the observation group after treatment were significantly lower than those of the control group (<jats:italic>P<\/jats:italic> &lt; 0.001). The observation group obtained a remarkably higher efficacy of ulcer healing under gastroscopy than the control group (<jats:italic>P<\/jats:italic> = 0.039). The observation group outperformed the control group in terms of the number of patients with excellent and good QOUH (<jats:italic>P<\/jats:italic> = 0.003, 0.014), but no statistical difference in the number of patients with poor QOUH between the two groups was found (<jats:italic>P<\/jats:italic> &gt; 0.05). Serum NO, EGF, and PGE2 levels of the observation group after treatment were significantly better than those of the control group (<jats:italic>P<\/jats:italic> &lt; 0.001). <jats:italic>Conclusion<\/jats:italic>. Erzhu Yiren Decoction can relieve the clinical symptoms of patients with gastric ulcers of spleen deficiency and dampness heat; improve the serum NO, EGF, and PGE2 levels; optimize the mucosal maturity; and enhance the overall efficacy, which merits clinical promotion.<\/jats:p>","DOI":"10.1155\/2022\/6495181","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T15:50:25Z","timestamp":1644249025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Trial Exploring Erzhu Yiren Decoction in Gastric Ulcer with Spleen Deficiency and Dampness\u2010Heat"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-0301","authenticated-orcid":false,"given":"Zhaowei","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40011-018-1023-8"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12713"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2019.07.001"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2020-0725"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.21608\/besps.2014.34798"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.06.012"},{"key":"e_1_2_7_7_2","first-page":"3028","article-title":"Study on regulation effect of troxipide on gastric ulcer induced by acetic acid in rats","volume":"36","author":"Li Mengran","year":"2019","journal-title":"Chinese Journal of Modern Applied Pharmacy"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5125568"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nel106"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2020.101209"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1089176"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-4964(17)60344-3"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1254\/jpssuppl.WCP2018.0_PO3-5-15"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00966"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.06.036"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.22159\/ajpcr.2018.v11i10.28494"},{"key":"e_1_2_7_17_2","unstructured":"ZhengX. Y. Guiding principles of clinical research on new drugs of Chinese medicines 2002."},{"key":"e_1_2_7_18_2","first-page":"15","article-title":"Consensus on epigastralgia diagnosis and treatment of Chinese Medicine (2017)","volume":"4","author":"Shengsheng Z.","year":"2018","journal-title":"World Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2016.67.6.318"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2174\/1386207323999201117114008"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3546258"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1556\/2060.105.2018.4.30"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113104"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2020.20022"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111345"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.191569"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24499"},{"key":"e_1_2_7_28_2","article-title":"The influence of Dahuang Huanglian Xiexin decoction and Lizhong pill on TXB_2 contents in serum on gastric ulcer model induced by pylorus deligation or smearing acetic acid combined with cold or heat syndrome rats","volume":"4","author":"Ji L. I.","year":"2011","journal-title":"Acta Chinese Medicine and Pharmacology"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.11.026"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00889.x"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6495181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6495181.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/6495181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T08:18:36Z","timestamp":1735633116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/6495181"}},"subtitle":[],"editor":[{"given":"Kazim","family":"Husain","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/6495181"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6495181","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6495181"}}