{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:02:13Z","timestamp":1790193733224,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,2,8]]},"abstract":"<jats:p>Cardiomyocyte apoptosis, neural remodeling, and gap junction channel change play critical roles in ventricular arrhythmia (VA) after acute myocardial infarction (AMI). Urolithin B (UB), one of the gut metabolites of ellagitannins, a class of antioxidant polyphenols, has various biological activities, but its direct role in cardiomyocyte apoptosis, neural remodeling, and gap junction channel change after AMI remains elusive. We investigated whether urolithin B reduced susceptibility of myocardial arrhythmic after myocardial infarction (MI). In vitro, the cardiomyocytes were subjected to hypoxia (94% N2\/5% CO2\/1% O2) for 3 hours. Cardiomyocyte apoptosis was assessed by TUNEL staining and western blotting. Urolithin B was found to decrease the number of apoptotic cells after hypoxia. Moreover, there was a substantial decrease in the expression of neural remodeling markers in the urolithin B treatment group. Urolithin B significantly increased the expression level of gap junction channel protein. Mechanistically, urolithin B inhibited cardiomyocyte apoptosis by activating Akt\/the mammalian target of rapamycin (mTOR) pathway, and the protection of urolithin B against cardiomyocyte apoptosis was compromised with Akt gene silencing. Furthermore, urolithin B suppressed nuclear translocation of nuclear factor-kB (NF-\u03baB) to facilitate nerve remodeling. Taken together, our findings suggested that UB reduced the occurrence of myocardial arrhythmias after hypoxia via regulation of the Akt\/mTOR pathway and NF-\u03baB nuclear translocation, which highlights the potential of UB as a novel therapy for ischemic heart disease.<\/jats:p>","DOI":"10.1155\/2022\/6517266","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T17:35:09Z","timestamp":1644341709000},"page":"1-11","source":"Crossref","is-referenced-by-count":11,"title":["Urolithin B, a Gut Microbiota Metabolite, Reduced Susceptibility to Myocardial Arrhythmic Predisposition after Hypoxia"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang 330008, China"},{"name":"Department of Cardiology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Affiliated Hospital of Sun Yat-sen University, Nanchang 330008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Affiliated Hospital of Sun Yat-sen University, Nanchang 330008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Affiliated Hospital of Sun Yat-sen University, Nanchang 330008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-7851","authenticated-orcid":true,"given":"Zeqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang 330008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"G. 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