{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:14:41Z","timestamp":1792955681122,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":105,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"VAN YYU Scientific Research Projects","award":["FYL-2020-9218"],"award-info":[{"award-number":["FYL-2020-9218"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . This study aimed to investigate the effects of gallic acid and silymarin against nephrotoxicity and hepatotoxicity caused by cisplatin.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . In the study, 56 Wistar Albino rats were equally divided into eight groups. Group 1 was the control group; group 2 was the group receiving cisplatin; group 3 was the group receiving cisplatin\u2009+\u2009gallic acid; group 4 was the group receiving cisplatin\u2009+\u2009silymarin; group 5 was the group receiving cisplatin\u2009+\u2009silymarin\u2009+\u2009gallic acid; group 6 was the group receiving silymarin; group 7 was the group receiving gallic acid; group 8 was the group receiving gallic acid\u2009+\u2009silymarin. AST, ALT, urea, creatinine, albumin, globulin, and total protein levels were measured at the end of the study. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione (GSH), and 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8OH\u2010dG) levels were measured in kidney and liver tissues. Additionally, histopathological evaluations of the tissues were also performed.\n                    <jats:italic>Results<\/jats:italic>\n                    . In kidney and liver tissues, cisplatin significantly increased MDA and 8\u2010OHdG levels compared with treatment groups (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Silymarin\u2010treated group significantly increased the SOD activity and GSH amount in the liver tissue compared with the cisplatin\u2010treated group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Gallic acid significantly increased CAT activity compared with the cisplatin\u2010treated group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). It was determined that the cisplatin\u2010treated group significantly decreased CAT and SOD activity compared with the control group (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). Gallic acid showed a significant increase in CAT and SOD activity in kidney tissue compared with the cisplatin\u2010treated group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . As a result, it was observed that gallic acid silymarin had a protective effect on cisplatin\u2010induced nephrotoxic and hepatotoxic effects.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6541026","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T16:20:09Z","timestamp":1650126009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Protective Effect of Silymarin and Gallic Acid against Cisplatin\u2010Induced Nephrotoxicity and Hepatotoxicity"],"prefix":"10.1155","volume":"2022","author":[{"given":"Duygu","family":"Do\u011fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-6665","authenticated-orcid":false,"given":"\u0130smet","family":"Meydan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-9251","authenticated-orcid":false,"given":"Ahmet Ufuk","family":"K\u00f6m\u00fcro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"251","article-title":"Inhibition of free radicals and antioxidant foods","volume":"33","author":"Ekici L.","year":"2008","journal-title":"Food"},{"key":"e_1_2_11_2_2","first-page":"442","article-title":"The role of glutathione in the antioxidant mechanism","volume":"22","author":"Aksoy Y.","year":"2002","journal-title":"Turkiye Klinikleri Medical Sciences"},{"key":"e_1_2_11_3_2","first-page":"109","article-title":"Snacks containing antioxidant and phenolic substances in nutrition","volume":"5","author":"G\u00fcle\u015f\u00e7i N.","year":"2016","journal-title":"G\u00fcm\u00fc\u015fhane University Journal of Health Science"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2017.1305297"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14030"},{"key":"e_1_2_11_6_2","first-page":"308","article-title":"Silymarin, a promising pharmacological agent for treatment of diseases","volume":"14","author":"Karimi G.","year":"2011","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.021"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.03.011"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2018.03.001"},{"key":"e_1_2_11_10_2","article-title":"Free radicals and tissue injury: fact and fiction","volume":"8","author":"Slater T. 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