{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:17:58Z","timestamp":1766269078399,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2022,6,22]]},"abstract":"<jats:p>Background. Re-operative mitral valve (MV) replacement is a high-risk procedure, therefore, transcatheter MV replacement (TMVR) is a promising therapeutic option. Aim. In this study, we aimed to evaluate the feasibility and safety of TMVR in patients with high surgical risk with degenerated mitral bioprostheses (TMViV), failed surgical rings (TMViR), and mitral annular calcification (TMViMAC). Methods. This is a retrospective cohort study that enrolled patients with high surgical risk who underwent TMVR from February 2017 to September 2020. The TMVR procedure was performed using Edwards SAPIEN-3 valves through the transseptal approach. Results. Sixty-four patients aged 62.7\u2009\u00b1\u200916.1 years with an STS score of 9.2\u2009\u00b1\u20093.7% underwent TMVR [35 (55%) TMViV, 16 (25%) TMViR, and 13 (20%) TMViMAC]. Mitral stenosis was more frequent in TMViV, mitral regurgitation was more frequent in TMViR, and combined mitral stenosis and regurgitation were more frequent in TMViMAC (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The MV gradient was 14.3\u2009\u00b1\u20095.3\u2009mmHg and the MV area was 1.5\u00b10.6\u2009cm2. The 29\u2009mm valve was frequently used in TMViV and TMViMAC, while the 23\u2009mm valve was frequently used in TMViR (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:msup>\n                           <c:mrow>\n                              <c:mn>0.003<\/c:mn>\n                           <\/c:mrow>\n                           <c:mi>\u2217<\/c:mi>\n                        <\/c:msup>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The procedural and fluoroscopy times were 58.7\u2009\u00b1\u20098.9 and 41.1\u2009\u00b1\u20098.2 minutes, respectively. Technical success was reported in 62 (98.4%) patients; 1 TMViR patient experienced valve embolization and salvage surgery, and 1 TMViMAC patient experienced slight valve malposition. At 3 months, 2 (3.1%) patients showed valve thrombosis (treated with anticoagulation), and 1 (1.6%) patient developed a paravalvular leak (underwent surgical MV replacement). At 6 months, 3 (4.7%) patients showed valve degeneration (underwent surgical MV replacement). Throughout follow-up, no patient exhibited mortality. Conclusions. TMVR is a feasible and safe approach in patients with high surgical risk. TMViV and TMViR are reasonable as the first treatment approaches, and TMViMAC seems encouraging.<\/jats:p>","DOI":"10.1155\/2022\/6587036","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T17:05:57Z","timestamp":1655917557000},"page":"1-17","source":"Crossref","is-referenced-by-count":6,"title":["Transcatheter Mitral Valve Replacement in High-Surgical Risk Patients: A Single-Center Experience and Outcome"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-7167","authenticated-orcid":true,"given":"Fatma A.","family":"Taha","sequence":"first","affiliation":[{"name":"Adult Cardiology Department, Madinah Cardiac Center, Madinah, Saudi Arabia"},{"name":"Cardiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham","family":"Naeim","sequence":"additional","affiliation":[{"name":"Adult Cardiology Department, Madinah Cardiac Center, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fareed","family":"Alnozha","sequence":"additional","affiliation":[{"name":"Adult Cardiology Department, Madinah Cardiac Center, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Amoudi","sequence":"additional","affiliation":[{"name":"Adult Cardiology Department, Madinah Cardiac Center, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda","family":"Abuelatta","sequence":"additional","affiliation":[{"name":"Adult Cardiology Department, Madinah Cardiac Center, Madinah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)69208-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307020"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.723"},{"key":"4","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"H. Baumgartner","year":"2017","journal-title":"European Heart Journal"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)00558-4"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311412"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.058"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.07.026"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.714"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.08.014"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy590"},{"article-title":"Mitral trial (mitral implantation of transcatheter valves) clinical trials. gov identifier nct02370511","year":"2021","author":"M. Guerrero","key":"12"},{"key":"13","article-title":"30-day outcomes of transcatheter mitral valve replacement in patient with severe mitral valve disease secondary to mitral annular calcification of failed annuloplasty rings","volume":"13","author":"M. Guerrero","year":"2017","journal-title":"Circulation"},{"article-title":"An instant guide to valve in valve procedures for clinicians developed by Dr. Vinayak Bapat, MD (UBQO)","year":"2021","author":"The VIV (Mitral) Application","key":"14"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-16-00209"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.924613"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.115.002135"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.022"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy271"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9485247"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.119.008425"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.068"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.061"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312047"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.116.005331"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.13767"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22866"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu103"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.065"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.01.017"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27447"},{"article-title":"Lampoon study: intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction during transcatheter mitral valve implantation","year":"2021","author":"R. J. Lederman","key":"32"},{"article-title":"Surgical implantation of transcatheter valve in native mitral annular calcification (sitral) study","year":"2021","author":"R. Smith","key":"33"},{"key":"34","first-page":"182","article-title":"Predictors of left ventricular outflow tract obstruction after transcatheter mitral valve replacement","volume":"12","author":"S. H. Yoon","year":"2019","journal-title":"JACC: Cardiovascular Interventions"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11I10A221"},{"key":"36","first-page":"381","article-title":"Anatomical challenges for transcatheter mitral valve intervention","volume":"57","author":"O. De Backer","year":"2016","journal-title":"The Journal of Cardiovascular Surgery"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.08.012"},{"issue":"10","key":"38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2016.11.033","article-title":"2016 Annual report of the society of thoracic Surgeons\/American College of Cardiology transcatheter valve therapy registry","volume":"69","author":"F. L. Grover","year":"2017","journal-title":"Journal of the American College of Cardiology"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.054"}],"container-title":["Journal of Interventional Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jitc\/2022\/6587036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jitc\/2022\/6587036.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jitc\/2022\/6587036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T17:06:05Z","timestamp":1655917565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jitc\/2022\/6587036\/"}},"subtitle":[],"editor":[{"given":"Martin J.","family":"Swaans","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,22]]},"references-count":39,"alternative-id":["6587036","6587036"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6587036","relation":{},"ISSN":["1540-8183","0896-4327"],"issn-type":[{"type":"electronic","value":"1540-8183"},{"type":"print","value":"0896-4327"}],"subject":[],"published":{"date-parts":[[2022,6,22]]}}}