{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:22:33Z","timestamp":1762161753953,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,5,26]]},"abstract":"<jats:p>Purpose. The present study investigated the prevalence of keratoconus (KC) among first-degree relatives of KC patients in Central China. Methods. From July 2018 to March 2022, 661 first-degree relatives of 384 KC patients were included in the present study. Corneal tomography, uncorrected distance visual acuity, manifest refraction with corrected distance visual acuity, intraocular pressure, slit-lamp microscopy, and fundus examination were performed. The diagnosis of KC was based on the Belin\/Ambrosio enhanced ectasia total deviation value (BAD-D value) on the Pentacam\u00ae system (Oculus GmbH). BAD-D value &lt;1.6 was diagnosed as healthy, 1.6\u2264 BAD-D value &lt;2.6 was diagnosed as suspected KC, and BAD-D value \u22652.6 was diagnosed as KC. Results. The present study included 337 (50.98%) female and 324 (49.02%) male subjects. The prevalence of KC and suspected KC in first-degree relatives was 8.77% (n\u2009=\u200958) and 29.05% (n\u2009=\u2009192), respectively. The prevalence of KC was 9.70% among parents and 7.23% among siblings. Conclusions. The higher prevalence of KC among first-degree relatives of patients with KC suggests that first-degree relatives of KC are at high risk of developing KC.<\/jats:p>","DOI":"10.1155\/2022\/6609531","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T07:35:07Z","timestamp":1653636907000},"page":"1-5","source":"Crossref","is-referenced-by-count":8,"title":["A Hospital-Based Study on the Prevalence of Keratoconus in First-Degree Relatives of Patients with Keratoconus in Central China"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yawen","family":"Wang","sequence":"first","affiliation":[{"name":"Henan University People\u2019s Hospital, Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People\u2019s Hospital, Henan University People\u2019s Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaopei","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinxiang Medical University, Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaili","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People\u2019s Hospital, Henan University People\u2019s Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Gu","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People\u2019s Hospital, Henan University People\u2019s Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Fan","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People\u2019s Hospital, Henan University People\u2019s Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University People\u2019s Hospital, Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhengzhou University People\u2019s Hospital, Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institution, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Guo","sequence":"additional","affiliation":[{"name":"Zhengzhou University People\u2019s Hospital, Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institution, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjiu","family":"Pang","sequence":"additional","affiliation":[{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People\u2019s Hospital, Henan University People\u2019s Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-1102","authenticated-orcid":true,"given":"Shengwei","family":"Ren","sequence":"additional","affiliation":[{"name":"Henan University People\u2019s Hospital, Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"},{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People\u2019s Hospital, Henan University People\u2019s Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-6056","authenticated-orcid":true,"given":"Dongqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Henan University People\u2019s Hospital, Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China"},{"name":"Henan Provincial People\u2019s Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People\u2019s Hospital, Henan University People\u2019s Hospital, Zhengzhou 450003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6257(97)00119-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000000408"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000002150"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.11.017"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-121219-081723"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02448.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112142-20191008-00200"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000002546"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12706"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3980\/j.issn.2222-3959.2010.01.17"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e318165d110"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.05.032"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31816f5edc"},{"issue":"5","key":"14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/1096-8628(20000828)93:5<403::AID-AJMG11>3.0.CO;2-A","article-title":"Genetic epidemiological study of keratoconus: evidence for major gene determination","volume":"93","author":"Y. Wang","year":"2000","journal-title":"American Journal of Medical Genetics"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2009.01908.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12389"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12005"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.03.040"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.130294"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.074955"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200303000-00008"},{"key":"22","first-page":"2537","article-title":"Baseline findings in the collaborative longitudinal evaluation of keratoconus (CLEK) study","volume":"39","author":"K. Zadnik","year":"1998","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"23","first-page":"61","article-title":"Clinical and epidemiological features of keratoconus genetic and external factors in the pathogenesis of the disease","volume":"178","author":"A. Ihalainen","year":"1986","journal-title":"Acta Ophthalmologica. Supplementum"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/iio.0b013e31820f1d2d"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87291-y"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039313"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2022\/6609531.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2022\/6609531.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2022\/6609531.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T07:35:19Z","timestamp":1653636919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2022\/6609531\/"}},"subtitle":[],"editor":[{"given":"Zisis","family":"Gatzioufas","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":26,"alternative-id":["6609531","6609531"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6609531","relation":{},"ISSN":["2090-0058","2090-004X"],"issn-type":[{"type":"electronic","value":"2090-0058"},{"type":"print","value":"2090-004X"}],"subject":[],"published":{"date-parts":[[2022,5,26]]}}}