{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:03:23Z","timestamp":1784574203167,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Scientific Research Projects of Anhui","award":["KJ2019A0442"],"award-info":[{"award-number":["KJ2019A0442"]}]},{"name":"University Scientific Research Projects of Anhui","award":["KJ2020A0401"],"award-info":[{"award-number":["KJ2020A0401"]}]},{"name":"University Scientific Research Projects of Anhui","award":["2015\u201324"],"award-info":[{"award-number":["2015\u201324"]}]},{"name":"University Scientific Research Projects of Anhui","award":["2021-zlgcfy017"],"award-info":[{"award-number":["2021-zlgcfy017"]}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["KJ2019A0442"],"award-info":[{"award-number":["KJ2019A0442"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["KJ2020A0401"],"award-info":[{"award-number":["KJ2020A0401"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["2015\u201324"],"award-info":[{"award-number":["2015\u201324"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["2021-zlgcfy017"],"award-info":[{"award-number":["2021-zlgcfy017"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anhui University of Chinese Medicine Project","award":["KJ2019A0442"],"award-info":[{"award-number":["KJ2019A0442"]}]},{"name":"Anhui University of Chinese Medicine Project","award":["KJ2020A0401"],"award-info":[{"award-number":["KJ2020A0401"]}]},{"name":"Anhui University of Chinese Medicine Project","award":["2015\u201324"],"award-info":[{"award-number":["2015\u201324"]}]},{"name":"Anhui University of Chinese Medicine Project","award":["2021-zlgcfy017"],"award-info":[{"award-number":["2021-zlgcfy017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,1,13]]},"abstract":"<jats:p>Objective. The aim of this study was to evaluate the effects of a modified Xiaohua Funing decoction (Xfd) on acute liver failure (ALF) and determine whether the protective mechanisms are related to alterations in the gut microbiota. Methods. An animal model of ALF was induced by intraperitoneal injection of D-galactosamine (D-Gal, 0.5\u2009g\/kg) and lipopolysaccharide (LPS, 100\u2009\u03bcg\/kg). Male BALB\/c mice were randomly divided into the following 4 groups: the control group (saline, Con), model group (D-Gal\/LPS, Mod), silymarin pretreatment group (200\u2009mg\/kg, Sil), and modified Xfd pretreatment group (650\u2009mg\/kg, Xfd). The Sil and Xfd groups received the respective intervention orally for 14 days and 2\u2009h before D-Gal\/LPS treatment. The liver injury markers included alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and liver histology. 16S rRNA gene sequencing was performed to assess the effects on the caecum content. Results. D-Gal\/LPS treatment caused severe ALF, illustrating that the ALF model was successfully established. The administration of Sil and Xfd greatly reduced the serum ALT and AST levels and improved the pathological signs of liver injury. However, no significant difference was found between the two groups. In contrast to the Mod group, the Sil and Xfd groups showed a shift toward the Con group in terms of the gut microbiota structure. The abundances of Firmicutes and Bacteroidetes and the Bacteroidetes\/Firmicutes ratio in the Mod group significantly differed from those in the Con group. The Sil and Xfd groups showed restoration of the disordered microbiota. Significantly increased relative abundances of Lachnospiraceae_NK4A136_group and Candidatus_Saccharimonas and a markedly decreased Muribaculaceae abundance were found in the Sil and Xfd mice compared with those in the Mod mice (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Interestingly, a negative correlation was observed between the abundances of the gut microbiota constituents, specifically Clostridia_UCG-014, and ALT and AST levels. Conclusion. In summary, our results indicate that Xfd may protect the liver and modify the gut microbiota in ALF mice.<\/jats:p>","DOI":"10.1155\/2022\/6611563","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T02:35:06Z","timestamp":1642127706000},"page":"1-13","source":"Crossref","is-referenced-by-count":6,"title":["The Protective Effects of a Modified Xiaohua Funing Decoction against Acute Liver Failure in Mice Induced by D-Gal and LPS"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0005-1820","authenticated-orcid":true,"given":"Jindong","family":"Zhao","sequence":"first","affiliation":[{"name":"Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China"},{"name":"Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Information, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-1534","authenticated-orcid":true,"given":"Zhaohui","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7640-7216","authenticated-orcid":true,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3239-4254","authenticated-orcid":true,"given":"Guoliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i42.12125"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.93"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.02.005"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/mcc.0b013e3282f6a420"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.30.20160060"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301733"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.06.028"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s180969"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8108503"},{"issue":"6","key":"10","first-page":"2395","article-title":"Brief analysis of the \u201832 words\u2019 liver regulating method proposed by traditional Chinese medicine master XU Jing-shi","volume":"33","author":"Y. Wang","year":"2018","journal-title":"Chinese Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"5","key":"11","first-page":"981","article-title":"Clinical observation of xiaohuafuning decoction in treatment of chronic atrophic gastritis with syndrome of liver-stagnation and spleen-deficiency","volume":"42","author":"G. L. Zhang","year":"2015","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"issue":"22","key":"12","first-page":"64","article-title":"Effect of Xiaohua funing decoction on ERK1\/2 and p-ERK1\/2 in rats with liver stagnation and spleen deficiency-type chronic atrophic gastritis","volume":"34","author":"G. L. Zhang","year":"2015","journal-title":"Journal of Anhui University of Chinese Medicine"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.11.260"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.11.5939"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932761"},{"key":"16","volume-title":"The Pharmacopoeia of the People\u2019s Republic of China","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2604"},{"key":"18","first-page":"892","volume-title":"Clostridium perfringens Poisoning, Poisoning and Toxicology Handbook,","author":"J. B. Leikin","year":"2008","edition":"4th."},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1128\/aem.03006-05"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2007.00375.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2017.78.5.252"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312670"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-236380"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.05.015"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.2174\/1568005014606143"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.121"},{"issue":"15","key":"27","first-page":"1288","article-title":"Analysis on medication rules of professor XU Jingshi in treating stomachache of stagnation of liver qi stagnation and spleen deficiency type: based on data mining","volume":"58","author":"Y. Li","year":"2017","journal-title":"Journal of Traditional Chinese Medicine"},{"issue":"3","key":"28","first-page":"562","article-title":"The relationship between TCM syndrome types and ALT, DNA HBV and liver tissue pathology in patients with chronic hepatitis B","volume":"12","author":"L. L. Liu","year":"2017","journal-title":"World Chinese Medicine"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.12659\/msm.909996"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.02.022"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103553"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.09.174"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.11.005"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2828"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3539748"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112333"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316723"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0011-z"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14397"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/nature13568"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26319"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.01.007"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.3390\/md17080455"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.055"},{"issue":"5","key":"45","first-page":"2325","article-title":"The effect of polyene phosphatidyl choline intervention on nonalcoholic steatohepatitis and related mechanism","volume":"8","author":"M. Cao","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1495"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/nature25019"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02948"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6308021"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042839"},{"issue":"8","key":"51","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3748\/wjg.v27.i8.708","article-title":"Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats","volume":"27","author":"J. D. Zhao","year":"2021","journal-title":"World Journal of Gastroenterology"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/6611563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/6611563.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/6611563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T02:35:21Z","timestamp":1642127721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/6611563\/"}},"subtitle":[],"editor":[{"given":"Jos\u00e9 Roberto","family":"Santin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,13]]},"references-count":51,"alternative-id":["6611563","6611563"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6611563","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,13]]}}}