{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T05:06:17Z","timestamp":1748063177715,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2018ZX09734-002","81803930"],"award-info":[{"award-number":["2018ZX09734-002","81803930"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018ZX09734-002","81803930"],"award-info":[{"award-number":["2018ZX09734-002","81803930"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:p>The aim of this study was to systematically review the efficacy and safety of Shuxuening injection combined with conventional Western medicine in the treatment of unstable angina. Randomized controlled trials of Shuxuening injection combined with conventional Western medicine in the treatment of unstable angina were searched by the computer system from PubMed, EMBASE, Cochrane Library, VIP, CNKI, Wanfang Database, and Chinese Biomedical Database since the establishment of the database until June 2020, according to the inclusion and exclusion criteria for the selection of literature, using Rev Man5.3 Meta-analysis Software. The 28 randomized controlled trials were included, with a total of 3,127 patients. Meta-analysis results showed that Shuxuening injection combined with conventional western medicine was effective in improving the clinical efficacy of angina pectoris (RR\u2009=\u20091.23, 95% CI [1.19, 1.27], P&lt;0.00001), improvement of ECG (RR\u2009=\u20091.31, 95% CI [1.23, 1.40], P &lt; 0.00001), reduction of angina pectoris attack frequency (MD\u2009=\u2009\u22121.28, 95% CI [\u22121.88, -0.67], P &lt; 0.0001), duration of angina (MD\u2009=\u2009\u22123.36, 95% CI [\u22123.69, \u22123.03], P &lt; 0.00001), nitroglycerin dosage (MD\u2009=\u2009-0.39, 95% CI [\u22120.65, \u22120.13], P\u2009=\u20090.003), C-reactive protein (MD\u2009=\u2009\u22122.72, 95% CI [\u22123.41, \u22122.03], P &lt; 0.00001), BNP (MD\u2009=\u2009\u221223.33, 95% CI [\u221227.87, \u221218.79], P &lt; 0.00001), lower triglycerides (MD\u2009=\u2009\u22120.72, 95% CI [\u22121.05, \u22120.38], P &lt; 0.0001), total cholesterol (MD\u2009=\u2009\u22121.39, 95% CI [\u22121.84, \u22120.94], P &lt; 0.00001), and LDL cholesterol (MD\u2009=\u2009-1.20, 95% CI [\u22122.12, \u22120.29], P\u2009=\u20090.01) which is better than that of control group. The effect on raising HDL cholesterol was comparable between the two groups (MD\u2009=\u20090.49, 95% CI [\u22120.06, 1.04], P\u2009=\u20090.08) and the incidence of adverse reactions to differences had no statistical significance (RR\u2009=\u20090.99, 95% CI [0.54, 1.81], P\u2009=\u20090.97). The Shuxuening injection combined with conventional Western medicine in the treatment of unstable angina has clear efficacy and a certain degree of safety, so it is recommended for clinical application.<\/jats:p>","DOI":"10.1155\/2022\/6650763","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T20:06:15Z","timestamp":1644955575000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["Systematic Review of the Efficacy and Safety of Shuxuening Injection in the Treatment of Unstable Angina"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9270-0957","authenticated-orcid":true,"given":"Genhao","family":"Fan","sequence":"first","affiliation":[{"name":"Tianjin University of Chinese Medicine, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-123X","authenticated-orcid":true,"given":"Menglin","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin University of Chinese Medicine, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8425-0151","authenticated-orcid":true,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7887-1242","authenticated-orcid":true,"given":"Xixi","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin University of Chinese Medicine, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7562-2427","authenticated-orcid":true,"given":"Yuhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"11","key":"1","first-page":"51","article-title":"New progress in the diagnosis and treatment of unstable angina","volume":"21","author":"Y. 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