{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:06:15Z","timestamp":1781183175030,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Sepsis remains a complicated and incompletely understood syndrome, and myocardial dysfunction is one of the main complications contributing to poor clinical outcomes. Accumulating evidence has revealed the critical involvement of the deregulated expression of specific microRNAs (miRNAs) in cardiac pathologies caused by sepsis. Intriguingly, miR\u2010377 has been correlated with cardiomyocyte apoptosis, whereas its effect on myocardial hypertrophy remains to be illustrated. Thus, the current study sets out to explore the impact and underlying mechanism of miR\u2010377 on myocardial hypertrophy induced by sepsis. The expression pattern of miR\u2010377 was detected in myocardial tissues of septic mice induced by cecal ligation\u2010perforation (CLP). We found that miR\u2010377 was highly expressed in myocardial tissues of CLP\u2010induced septic mice with cardiomyocyte hypertrophy. Besides, miR\u2010377 inhibition could relieve cardiomyocyte hypertrophy and reduce inflammation in septic mice. Further, mechanistic studies found that miR\u2010377 could target Rcan2 and then regulate calcineurin (CaN) activity via Ca<jats:sup>2+<\/jats:sup>\/CaN signaling pathway. Collectively, our findings illuminate that miR\u2010377 enhances myocardial hypertrophy caused by sepsis, by targeting Rcan2 and further regulating the Ca<jats:sup>2+<\/jats:sup>\/CaN signaling pathway. This work highlights downregulation of miR\u2010377 as a novel target for the management of sepsis\u2010induced myocardial hypertrophy.<\/jats:p>","DOI":"10.1155\/2022\/6659183","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:38:46Z","timestamp":1665535126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Overexpression of miR\u2010377 Aggravates Sepsis\u2010Induced Myocardial Hypertrophy by Binding to Rcan2 and Mediating CaN Activity"],"prefix":"10.1155","volume":"2022","author":[{"given":"Shiji","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-5050","authenticated-orcid":false,"given":"Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201910-1911TR"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0736"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.10.011"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002639"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003050"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0142-5"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2015.07.008"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150915891"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805038105"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000268088"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.009"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-510586"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.11.012"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085539"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805889200"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812544106"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12164"},{"key":"e_1_2_10_19_2","first-page":"671","article-title":"Regulator of calcineurin (rcan): beyond down syndrome critical region","volume":"43","author":"Lee S. 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