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However, it has many adverse effects on various organs especially on the liver. Thymol, one of the major components of thyme oil, has biological properties that include anti\u2010inflammatory and antioxidant activities. Thus, this study was designed to examine thyme oil and thymol for their ability to prevent doxorubicin\u2010induced hepatotoxicity in Wistar rats. Hepatotoxicity was induced by an intraperitoneal injection of doxorubicin, at a dose of 2\u2009mg\/kg bw\/week, for seven weeks. Doxorubicin\u2010injected rats were supplemented with thyme oil and thymol at doses 250 and 100\u2009mg\/kg bw, respectively, four times\/week by oral gavage for the same period. Treatment of rats with thyme oil and thymol reversed the high serum activities of AST, ALT, and ALP and total bilirubin, AFP, and CA19.9 levels, caused by doxorubicin. Thyme oil and thymol also reduced the high levels of TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and the decreased levels of both albumin and IL\u20104. These agents ameliorated doxorubicin\u2010induced elevation in hepatic lipid peroxidation and associated reduction in GSH content and GST and GPx activities. Further, the supplementation with thyme oil and thymol significantly augmented mRNA expression of the level of antiapoptotic protein Bcl\u20102 and significantly downregulated nuclear and cytoplasmic levels of the hepatic apoptotic mediator p53. Thus, thyme oil and thymol successfully counteracted doxorubicin\u2010induced experimental hepatotoxicity via their anti\u2010inflammatory, antioxidant, and antiapoptotic properties.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6702773","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T16:20:05Z","timestamp":1644250805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["[Retracted] Thyme Oil and Thymol Counter Doxorubicin\u2010Induced Hepatotoxicity via Modulation of Inflammation, Apoptosis, and Oxidative Stress"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-9709","authenticated-orcid":false,"given":"Osama M.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5013-693X","authenticated-orcid":false,"given":"Sanaa R.","family":"Galaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-2804","authenticated-orcid":false,"given":"Mennah-Allah M. 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