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Moreover, these compounds were estimated for their biological potential in terms of anti-diabetic, anti-cholinesterase, and anti-oxidant capacities. The compounds were synthesized through Michael addition of various ketones to N-aryl maleimides. Similarly, the MOE software was used for the molecular docking study to explore the binding mode of the potent compounds against different enzymes. In the anti-cholinesterase activity, the compounds MSJ2 and MSJ10 exhibited outstanding activity against acetylcholinesterase (AChE), i.e., 91.90, 93.20%, and against butyrylcholinesterase (BChE), i.e., 97.30, 91.36% inhibitory potentials, respectively. The compounds MSJ9 and MSJ10 exhibited prominent \u03b1-glucosidase inhibitory potentials, i.e., 87.63 and 89.37 with IC50 value of 32 and 28.04\u2009\u03bcM, respectively. Moreover, the compounds MSJ2 and MSJ10 revealed significant scavenging activity against DPPH free radicals with IC50 values of 2.59 and 2.52, while against ABTS displayed excellent scavenging potential with IC50 values 7.32 and 3.29\u2009\u03bcM, respectively. The tentative results are added with molecular docking studies in the active sites of enzymes to predict the theoretical protein-ligand binding modes. Further detailed mechanism-based studies in animal models are essential for the in vivo evaluation of the potent compound.<\/jats:p>","DOI":"10.1155\/2022\/6726438","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T18:35:16Z","timestamp":1659206116000},"page":"1-12","source":"Crossref","is-referenced-by-count":16,"title":["Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-\u03b1-Amylase, and Anti-\u03b1-Glucosidase: In Vitro and In Silico Approaches"],"prefix":"10.1155","volume":"2022","author":[{"given":"Osama M.","family":"Alshehri","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-5604","authenticated-orcid":true,"given":"Mater H.","family":"Mahnashi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-7863","authenticated-orcid":true,"given":"Abdul","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, KP 18000 Dir (L), Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehman","family":"Zafar","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-6510","authenticated-orcid":true,"given":"Muhammad Saeed","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Swabi, Swabi, KP, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhat","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, KP 18000 Dir (L), Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ali","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Collage of Applied Medical Sciences, Najran University, Najran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Alshamrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elhashimi E.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/1612197X.2020.1773195","article-title":"Physical activity, health and well-being in an imposed social distanced world","volume":"18","author":"A. 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