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Natural products with anti-inflammatory ability have played a great role in the process of overcoming these inflammatory diseases. In this study, we evaluated the anti-inflammatory activities of ten natural compounds derived from lotus seedpod and discovered (E)-9-octadecenoic acid ethyl ester (E9OAEE) inhibited the production of nitric oxide (NO) optimally in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Furthermore, we explored the effects of E9OAEE on inflammatory responses and the underlying mechanisms in LPS-induced RAW264.7 macrophages. The results indicated that E9OAEE significantly suppressed the production of NO, prostaglandin E2 (PGE2), and tumour necrosis factor-\u03b1 (TNF\u03b1) in a dose-dependent manner. The protein expression and mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX2) were inhibited by pretreatment of E9OAEE. Furthermore, E9OAEE restrained the phosphorylation of mitogen-activated protein kinase (MAPKs) family members, ERK, P38, and JNK stimulated by LPS-treated for 30\u2009min and prevented the nuclear translocation of nuclear factor-kappa B (NF-\u03baB) prompted by LPS-treated for 6\u2009h in RAW264.7 macrophages. Taken together, we discovered an anti-inflammatory component from lotus seedpod and identified E9OAEE attenuated the inflammatory response in LPS-induced RAW264.7 macrophages probably by regulating the activation of MAPKs and NF-\u03baB signalling pathways, which would provide some base for the development of new anti-inflammatory drugs.<\/jats:p>","DOI":"10.1155\/2022\/6731360","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T20:05:09Z","timestamp":1641413109000},"page":"1-9","source":"Crossref","is-referenced-by-count":29,"title":["(E)-9-Octadecenoic Acid Ethyl Ester Derived from Lotus Seedpod Ameliorates Inflammatory Responses by Regulating MAPKs and NF-\u03baB Signalling Pathways in LPS-Induced RAW264.7 Macrophages"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4647-1209","authenticated-orcid":true,"given":"Chuanqi","family":"Xie","sequence":"first","affiliation":[{"name":"Institute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufen","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China"},{"name":"Faculty of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-2638","authenticated-orcid":true,"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5338-4250","authenticated-orcid":true,"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Applied Chemistry, Jiangxi Academic of Sciences, Nanchang 330096, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297916110018"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01256-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1039\/c9fo02178g"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7207354"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9957451"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b02586"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114030"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3104057"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.4103\/pm.pm_479_16"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0494-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-020-00720-8"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01312-y"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.02.014"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/210736"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.959"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-010-9214-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0258-2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-015-0863-4"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112794"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050792"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3390\/life11040317"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25153394"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25173831"},{"key":"25","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.669638","article-title":"Natural compounds as medical strategies in the prevention and treatment of psychiatric disorders seen in neurological diseases","volume":"12","author":"E. 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