{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:04Z","timestamp":1787017864063,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074441"],"award-info":[{"award-number":["82074441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . To explore the rules of TCM medication in the treatment of constipation in network pharmacology.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Collect and screen the clinical intervention literature on TCM for constipation from China\u2019s national knowledge infrastructure, Wanfang and VIP databases established a database of TCM for constipation, applied R software (3.3.1) to analyze the pattern of prescriptions for TCM for constipation, and summarized the core prescription. The effective active compounds and action targets in the core prescription were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Traditional Chinese Medicine Integrated Databases (TCMID), constipation\u2010related targets were derived from the DisGeNET and GeneCards databases, Protein\u2010protein interaction network (PPI) was drawn by STRING database, and enrichment analysis was conducted by the Clusterprofiler package in R software (3.3.1). Finally, molecular docking was used to validate the binding ability of candidate compounds to potential targets.\n                    <jats:italic>Results<\/jats:italic>\n                    . Two hundred sixteen target prescriptions were screened through data mining, involving 226 herbs. Association rule analysis results suggested that the \u201cAngelicae sinensis\u2010Radix\u2010dried rehmanniae\u2010Cistanche deserticola\u2010Atractylodes macrocephala\u2010Astragali Radix\u201d was a strong affinity for medicine. Network pharmacology analysis of the core prescription resulted in the screening of 115 candidate compounds, such as quercetin, kaempferol, mangostin, eugenol A, and beta\u2010sitosterol; 131 potential targets, such as PTGS2, PTGS1, and CHRM3; and 160 signaling pathways, such as lipid and atherosclerosis, proteoglycans in cancer, hepatitis B, Kaposi\u2019s sarcoma\u2010associated herpesvirus infection, and PI3K\/AKT pathways. Molecular docking showed that PTGS1\u2010formononetin, PTGS2\u2010kaempferol, and CHRM3\u2010kaempferol were all well bound and well matched.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . This study provides a new method and ideas for clinical applications of integrated Chinese and western medicine in treating constipation.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6733851","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T17:35:05Z","timestamp":1665509705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Study on Medication Rules of Traditional Chinese Medicine in Treating Constipation through Data Mining and Network Pharmacology"],"prefix":"10.1155","volume":"2022","author":[{"given":"Shu-Min","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Peng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8114-9111","authenticated-orcid":false,"given":"Jin-Gen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-522X","authenticated-orcid":false,"given":"Qing-Jun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja18.00241"},{"key":"e_1_2_12_2_2","unstructured":"ZhengJ. 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