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Study results on the association between the serum level of vitamin D and asthma severity have suggested a converse relationship between lower vitamin D levels and more severe clinical courses. However, they are not consistent in these findings and have shown insignificant correlations, as well. The possible effects of vitamin D on asthma have led researchers to consider this vitamin a potential prophylactic and therapeutic tool for managing children with variant degrees of asthma. Adding vitamin D to the routine corticosteroid therapy of asthmatic children is another field of interest that has shown promising results. In this narrative review study, we aim to elaborate on the existing knowledge on the role of vitamin D in asthma pathogenesis and prognosis, explain the controversies that exist on the effectiveness of treating patients with vitamin D supplements, and make a general conclusion about how vitamin D actually is linked to asthma in children.<\/jats:p>","DOI":"10.1155\/2022\/6735900","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T15:45:27Z","timestamp":1657899927000},"page":"1-7","source":"Crossref","is-referenced-by-count":30,"title":["Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-8030","authenticated-orcid":true,"given":"Fardis","family":"Salmanpour","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"},{"name":"Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran"},{"name":"USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6577-2138","authenticated-orcid":true,"given":"Naghmeh","family":"Kian","sequence":"additional","affiliation":[{"name":"Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran"},{"name":"USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6429-7729","authenticated-orcid":true,"given":"Noosha","family":"Samieefar","sequence":"additional","affiliation":[{"name":"Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran"},{"name":"USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6415-8403","authenticated-orcid":true,"given":"Mohammad Amin","family":"Khazeei Tabari","sequence":"additional","affiliation":[{"name":"Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran"},{"name":"Mazandaran University of Medical Sciences, Sari, Iran"},{"name":"Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3836-1827","authenticated-orcid":true,"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran"},{"name":"Research Center for Immunodeficiencies, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S46944"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2016.1128326"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32834db288"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1288"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/nu5093605"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1689s"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1080s"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.04.002"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2021.07.005"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17279"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1361OC"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051233"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-020-00122-9"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136841"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12384"},{"key":"17","article-title":"Association of free vitamin D 3 concentrations and asthma treatment failures in the ViDA trial","author":"J. 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