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Osteoblastic differentiation of human aortic valve interstitial cells (HAVICs) induced by inflammation play a crucial role in CAVD pathophysiological processes. To date, no effective drugs for CAVD have been established, and new agents are urgently needed. Piericidin glycosides, obtained from a marine\u2010derived\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    strain, were revealed to have regulatory effects on mitochondria in previous studies. Here, we discovered that 13\u2010hydroxypiericidin A 10\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010D\u2010glucose (1\u21926)\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010D\u2010glucoside (S18), a specific piericidin diglycoside, suppresses lipopolysaccharide\u2010 (LPS) induced inflammatory responses of HAVICs by alleviating mitochondrial stress in an interleukin (IL)\u201037\u2010dependent manner. Knockdown of IL\u201037 by siRNA not only exaggerated LPS\u2010induced HAVIC inflammation and mitochondrial stress but also abrogated the anti\u2010inflammatory effect of S18 on HAVICs. Moreover, S18 alleviated aortic valve lesions in IL\u201037 transgenic mice of CAVD model. Microscale thermophoresis (MST) and docking analysis of five piericidin analogues suggested that diglycosides, but not monoglycosides, exert obvious IL\u201037\u2010binding activity. These results indicate that S18 directly binds to IL\u201037 to alleviate inflammatory responses in HAVICs and aortic valve lesions in mice. Piericidin diglycoside S18 is a potential therapeutic agent to prevent the development of CAVD.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6776050","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T01:35:39Z","timestamp":1660786539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["[Retracted] Marine\u2010Derived Piericidin Diglycoside S18 Alleviates Inflammatory Responses in the Aortic Valve via Interaction with Interleukin 37"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-0975","authenticated-orcid":false,"given":"Shunyi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-2951","authenticated-orcid":false,"given":"Jianglian","family":"She","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiji","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-7286","authenticated-orcid":false,"given":"Zichao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-5083","authenticated-orcid":false,"given":"Shuwen","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3121-8347","authenticated-orcid":false,"given":"Gaopeng","family":"Xian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-984X","authenticated-orcid":false,"given":"Zhendong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-6229","authenticated-orcid":false,"given":"Shaoping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-5507","authenticated-orcid":false,"given":"Xingbo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3193-4354","authenticated-orcid":false,"given":"Dingli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-0886","authenticated-orcid":false,"given":"Lan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-4869","authenticated-orcid":false,"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-8237","authenticated-orcid":false,"given":"Qingchun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.043391"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.10.006"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00862"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.08.029"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9579-6"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000227513.13697.ac"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.001115"},{"key":"e_1_2_11_8_2","doi-asserted-by":"crossref","unstructured":"MillerJ. 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