{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:09:45Z","timestamp":1782230985916,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Health Science and Technology Project of Zhejiang Provincial Health Commission","award":["2019KY492"],"award-info":[{"award-number":["2019KY492"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2022,1,25]]},"abstract":"<jats:p>Objective. To investigate the effect and safety of PRP and Yifu combined with ultrapulsed CO2 lattice laser in patients with sunken acne scar. Methods. 700 subjects were selected from the group of patients with sunken acne scar treated in our hospital from November 2010 to December 2020. They were divided into control group (n\u2009=\u2009350) and study group (n\u2009=\u2009350). The grouping was mainly based on the random number table method. Patients in the control group were treated with ultrapulse CO2 lattice laser, while those in the study group were treated with ultrapulse CO2 lattice laser combined with PRP and Yifu. The clinical effect, scar improvement and quality of life before and after treatment, and adverse events during treatment were compared between the two groups. The clinical effect was categorized into cure after treatment, significant effect, effective, and ineffective. The total effective rate\u2009=\u20091\u2009\u2212\u2009ineffective rate. Results. After treatment, the total effective rate of the study group (81.43%) was higher than that of the control group (70.00%). After treatment, ECCA, VSS scores, daily activities, symptoms and feelings, work and study, leisure and entertainment, interpersonal relationship, treatment status, and total scores were all lower in both groups than before treatment, and the study group was lower than the control group. During the treatment, the incidence of adverse events in the study group (17.33%) was lower than that in the control group (28.57%), <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>. Conclusion. PRP and Yifu combined with ultrapulse CO2 lattice laser in the treatment of sunken acne scar can effectively improve the scar, reduce the incidence of adverse events, and the treatment effect is obvious, which can improve the quality of life of the patients.<\/jats:p>","DOI":"10.1155\/2022\/6803988","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T23:50:31Z","timestamp":1643154631000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Effect and Safety Analysis of PRP and Yifu Combined with Ultrapulsed CO2 Lattice Laser in Patients with Sunken Acne Scar"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yuyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Zhuji Hospital of Traditional Chinese Medicine, Shaoxing 311800, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0405-8624","authenticated-orcid":true,"given":"Jinsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475418818073"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030683"},{"issue":"5","key":"3","first-page":"1","article-title":"Platelet-rich plasma (PRP): current applications in dermatology","volume":"24","author":"J. 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