{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:05:30Z","timestamp":1767168330975,"version":"build-2238731810"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jinhua Science and Technology Plan Public Welfare Projects","award":["2019-4-018"],"award-info":[{"award-number":["2019-4-018"]}]},{"name":"Jinhua Science and Technology Plan Public Welfare Projects","award":["2020-4-005"],"award-info":[{"award-number":["2020-4-005"]}]},{"name":"Jinhua Science and Technology Plan Public Welfare Projects","award":["2020-3-052"],"award-info":[{"award-number":["2020-3-052"]}]},{"name":"Key Projects of Jinhua Science and Technology Plan","award":["2019-4-018"],"award-info":[{"award-number":["2019-4-018"]}]},{"name":"Key Projects of Jinhua Science and Technology Plan","award":["2020-4-005"],"award-info":[{"award-number":["2020-4-005"]}]},{"name":"Key Projects of Jinhua Science and Technology Plan","award":["2020-3-052"],"award-info":[{"award-number":["2020-3-052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,10,3]]},"abstract":"<jats:p>\n                    The present work is aimed at exploring the clinical efficacy and safety of methotrexate (MTX) and leflunomide (LEF) combination therapy for rheumatoid arthritis. From June 2019 to June 2021, a total of 120 individuals with rheumatoid arthritis received a diagnosis. Sixty patients each were randomly assigned to the control and observation groups. The observation group received MTX and LEF combo medication while the control group only received MTX treatment. Clinical efficacy, complication incidence, and the alleviation of inflammatory markers, joint pain, and clinical symptoms were compared between the 2 groups. Posttreatment, the observation group had overall response rate of 96.66%, while the control group had 86.67%, with significant differences. Compared with pretreatment, both control and observation group patients showed decreasing trends of IL-1 levels and increasing trends of IL-10 levels posttreatment, with significant differences (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). Compared with the control group, patients in the observation group had lower IL-1 and TNF-\u03b1 levels with significant differences (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) and higher levels of IL-10 with significant difference (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). In both groups, the pain score and the number of painful joints were much lower than they were prior to treatment. Following treatment, the observation group displayed significantly lower levels of erythrocyte sedimentation rate, rheumatoid factor, and C-reactive protein than the control group (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). Clinical measures in the observation group were all lower than those in the control group with statistically significant differences (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). Moreover, the incidence rate of adverse reactions showed no significant difference between these 2 groups (\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&gt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ). In conclusion, the combination therapy of MTX and LEF is efficacious for rheumatic arthritis.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6829358","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T19:05:11Z","timestamp":1664823911000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Combination of Methotrexate and Leflunomide Is Efficient and Safe for 60 Patients with Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Fang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9744-098X","authenticated-orcid":true,"given":"Hongwei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"9","key":"1","first-page":"626","article-title":"Rheumatoid arthritis","volume":"39","author":"G. S. Ngian","year":"2010","journal-title":"Australian Family Physician"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"issue":"10","key":"3","first-page":"1906","article-title":"Adverse events with disease modifying antirheumatic drugs (DMARD): a cohort study of leflunomide compared with other DMARD","volume":"31","author":"G. W. Cannon","year":"2004","journal-title":"The Journal of Rheumatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1349-y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1177\/039463201102400136"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.07.004"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.789334"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.093690"},{"key":"9","volume-title":"Leflunomide, in Liver Tox: Clinical and Research Information on Drug-Induced Liver Injury","year":"2012"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200105000-00002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23253"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3177-x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2010.07.001"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000055"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/ar4414"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2014.13950"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.11.017"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1159\/000513879"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.53157"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.01.107"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2019.8223"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1502748"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6637554"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000736"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110467"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/ar4685"}],"updated-by":[{"DOI":"10.1155\/2023\/9801924","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"record-id":"60477"},{"DOI":"10.1155\/2023\/9801924","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/6829358.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/6829358.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/6829358.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T19:05:21Z","timestamp":1664823921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/6829358\/"}},"subtitle":[],"editor":[{"given":"Liaqat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,3]]},"references-count":26,"alternative-id":["6829358","6829358"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6829358","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,3]]}}}