{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:21:51Z","timestamp":1767165711408,"version":"build-2238731810"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":186,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["11786"],"award-info":[{"award-number":["11786"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["3985"],"award-info":[{"award-number":["3985"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Betamethasone is an important glucocorticoids (GCs), frequently used to cure allergies (such as asthma and angioedema), Crohn\u2019s disease, skin diseases (such as dermatitis and psoriasis), systemic lupus erythematosus, rheumatic disorders, and leukemia. Present investigation deals to find potential agonist of glucocorticoid receptors after biotransformation of betamethasone dipropionate (1) and to carry out the molecular docking and ADME analyses. Biotransformation of 1 was carried out with\n                    <jats:italic>Launaea capitata<\/jats:italic>\n                    (dandy) roots and\n                    <jats:italic>Musa acuminate<\/jats:italic>\n                    (banana) leaves.\n                    <jats:italic>M. acuminate<\/jats:italic>\n                    furnished low\u2010cost value\u2010added products such as Sananone dipropionate (2) in 5% yields. Further, biocatalysis of Sananone dipropionate (2) with\n                    <jats:italic>M. acuminate<\/jats:italic>\n                    gave Sananone propionate (3) and Sananone (4) in 12% and 7% yields, respectively. However, Sananone (4) was obtained in 37% yields from\n                    <jats:italic>Launaea capitata<\/jats:italic>\n                    . Compound 5 was obtained in 11% yield after\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010elimination of propionic acid at C\u201017 during oxidation of compound 1. The structure elucidation of new compounds 2\u20105 was accomplished through combined use of X\u2010ray diffraction and NMR (1D and 2D) studies. In addition to this, molecular docking and ADME analyses of all transformed products of 1 were also done. Compounds 1\u20105 showed \u201012.53 to \u201010.11\u2009kcal\/mol potential binding affinity with glucocorticoid receptor (GR) and good ADME profile. Moreover, all the compounds showed good oral bioavailability with the octanol\/water partition coefficient in the range of 2.23 to 3.65, which indicated that compounds 1\u20105 were in significant agreement with the given criteria to be considered as drug\u2010like.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6865472","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T19:50:13Z","timestamp":1657137013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[Retracted] Betamethasone Dipropionate Derivatization, Biotransformation, Molecular Docking, and ADME Analysis as Glucocorticoid 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