{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:02:17Z","timestamp":1784048537269,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Research Foundation of Guangdong Medical University","award":["GDMUQ2021035"],"award-info":[{"award-number":["GDMUQ2021035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,6,13]]},"abstract":"<jats:p>Objective. To investigate the correlation between tropomyosin (TM) and clinical characteristics of bladder cancer. In addition, the relationship between TM and immune cell infiltration in bladder cancer was further analyzed. Methods. Based on The Cancer Genome Atlas (TCGA) database, the relationship between TM expression and clinicopathological features in bladder cancer was analyzed. Receiver operating characteristic (ROC) curve was used to evaluate the value of TM as a diagnostic marker for bladder cancer. Univariate and multivariate Cox regression was used to analyze the independent factors affecting the prognosis of patients with bladder cancer. The relationship between TM and immune cell infiltration was analyzed. Results. ROC curve showed that TPM1, TPM2, and TPM3 had significant diagnostic ability (AUC was 0.845, 0.848, and 0.873, respectively). The high expression of TPM1 and TPM2 is associated with poor overall and disease-specific survival in patients with bladder cancer (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Multivariate Cox analysis showed that age and TPM1 were independent prognostic factors. The expression levels of TPM1, TPM2, TPM3, and TPM4 in low grade bladder cancer were lower than those in high grade bladder cancer (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). TPM1 and TPM2 are positively correlated with the infiltration of macrophages and NK cells in bladder cancer. TPM3 is positively associated with Th2. TPM4 is positively correlated with Th1 cells, macrophages, and neutrophils (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Conclusions. TPM1 and TPM2 are effective markers for the diagnosis of bladder cancer. TPM1 is an independent prognostic factor for bladder cancer. TM is also associated with the infiltration of various immune cells in bladder cancer. TM may have influenced the development of bladder cancer through immune inhibition.<\/jats:p>","DOI":"10.1155\/2022\/6936262","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T15:05:22Z","timestamp":1655132722000},"page":"1-13","source":"Crossref","is-referenced-by-count":15,"title":["Tropomyosin Is Potential Markers for the Diagnosis and Prognosis of Bladder Cancer"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9265-4623","authenticated-orcid":true,"given":"Yunkun","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sining","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"10","key":"1","first-page":"872","article-title":"Epidemiology, etiology and prevention of bladder cancer","volume":"73","author":"J. J. Rozanec","year":"2020","journal-title":"Archivos Espa\u00f1oles de Urolog\u00eda"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.539527"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2007"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28208"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2018.1480279"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.42151"},{"issue":"10","key":"7","first-page":"6524","article-title":"Prognostic significance of tumor-infiltrating immune cells in muscle-invasive bladder cancer","volume":"12","author":"Y. L. Peng","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.052"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.003"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1042\/bj0430271"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.08.031"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20151"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900222"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092692"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/6936262.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/6936262.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/6936262.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T15:05:29Z","timestamp":1655132729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/6936262\/"}},"subtitle":[],"editor":[{"given":"Gaetano","family":"Isola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,13]]},"references-count":14,"alternative-id":["6936262","6936262"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6936262","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,13]]}}}