{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:43:12Z","timestamp":1767890592328,"version":"3.49.0"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2022R30"],"award-info":[{"award-number":["PNURSP2022R30"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Celiac disease (CD) is a chronic inflammatory disorder in the intestinal tract as a response to the use of gluten in genetically predisposed individuals. It is a worldwide problem, with a high prevalence rate in North America. This is a descriptive cross\u2010sectional study involving 1090 samples collected from different hospitals of Rawalpindi and Islamabad, Pakistan, from January 2019 to December 2019. In this study, 1090 blood samples screened for seroprevalence of anti\u2010tTG antibodies in CD symptomatic patients via ELISA (enzyme\u2010linked immunosorbent assay). 1090 fecal samples from the same CD patients were collected and tested for the presence of rotavirus (RV) via ELISA and RT\u2010PCR. Of the 1090 patients tested for seroprevalence of anti\u2010tTG antibodies, 112\/1090 (10.3%) were found to be positive. Of the 112 anti\u2010tTG\u2010positive patients, 78\/112 (70%) were positive for RV via ELISA and 74\/112 (66.1%) were RV positive via RT\u2010PCR. A statistically significant association was reported between rotavirus infection and celiac disease (<jats:italic>p<\/jats:italic>\u02c20.05). Anti\u2010tTG antibodies were higher in age group 6 (12\u201018 years) patients (18.4%) and at minimum in age group 3 (1\u20103 years) patients (4.8%). However, there was a statistically insignificant relationship between group age and CD prevalence (<jats:italic>p<\/jats:italic> &gt; 0.05). The highest CD prevalence was noted during winter season (19.6%) and the lowest (3.0%) during fall\/autumn. Our study findings demonstrate that Pakistan has a high prevalence of CD compared to other studies. Further studies in the fields of environmental risk factors and treatment with more advanced serological and histopathological studies are needed in the future.<\/jats:p>","DOI":"10.1155\/2022\/6972624","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T22:05:08Z","timestamp":1663884308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Seroprevalence of Anti\u2010tTg\u2010IgA among Symptomized Celiac Disease Patients and Their Correlation with Rotavirus 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