{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:33:04Z","timestamp":1770834784131,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","award":["97200"],"award-info":[{"award-number":["97200"]}],"id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>This study is aimed at evaluating the effects of <jats:italic>Securigera securidaca<\/jats:italic> (SS) seed extract on cholestatic liver injury induced by bile duct ligation (BDL) in rats. Total polyphenols and flavonoids in SS seed extract were determined using a colorimetric assay, and their components were quantified using HPLC. Rats in four groups underwent BDL at the common bile duct and were treated for 21 days with either oral distilled water as vehicle, vitamin C, 100\u2009mg\/kg SS seed extract, or 200\u2009mg\/kg SS seed extract. Rats in the fifth group underwent abdominal incision without BDL and were treated with distilled water, and rats in the sixth group were healthy and received nothing. Finally, rats were sacrificed, blood samples were analyzed through biochemical methods, liver tissues were histologically assessed, and the expression of the TGF<jats:italic>\u03b2<\/jats:italic>\u20101, iNOS, caspase\u20103, and <jats:italic>\u03b1<\/jats:italic>\u2010SMA genes in the liver was assessed through real\u2010time PCR. BDL significantly increased, and SS seed extract significantly decreased the serum levels of bilirubin and liver function enzymes. Moreover, SS seed extract suppressed the expression of the TGF<jats:italic>\u03b2<\/jats:italic>\u20101, iNOS, caspase\u20103, and <jats:italic>\u03b1<\/jats:italic>\u2010SMA genes, reduced the levels of nitric oxide, malondialdehyde, and protein carbonyl, and increased the levels of glutathione, total antioxidant capacity, and SOD and catalase enzyme activity in the serum and liver. Extract at a dose of 100\u2009mg\/kg had significant positive effects on liver morphology and parenchyma structure in a dose\u2010dependent manner.<\/jats:p>","DOI":"10.1155\/2022\/6989963","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T19:20:09Z","timestamp":1644002409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Protective Effects of <i>Securigera securidaca<\/i> Seed Extract on Liver Injury Induced by Bile Duct Ligation in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-6756","authenticated-orcid":false,"given":"Zahra","family":"Nasehi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0684-7125","authenticated-orcid":false,"given":"Nejat","family":"Kheiripour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-133X","authenticated-orcid":false,"given":"Maryam Akhavan","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-1759","authenticated-orcid":false,"given":"Abolfazl","family":"Ardjmand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh","family":"Jozi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-9238","authenticated-orcid":false,"given":"Esmat","family":"Aghadavod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-419X","authenticated-orcid":false,"given":"Amir Hossein","family":"Doustimotlagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-3576","authenticated-orcid":false,"given":"Mohammad Esmaeil","family":"Shahaboddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.008"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327112474832"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007516"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.08.011"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr233"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300342"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.12.048"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.64380"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci118304"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.5.2569"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02138.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.2741\/gressner"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64043-6"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1076\/phbi.39.1.62.5949"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5131(03)01453-5"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.09.003"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2008.2619.2623"},{"key":"e_1_2_9_19_2","first-page":"3188","article-title":"To study the effects of Securigera securidaca (L.) seed against alloxan-induced hyperglycemia","volume":"5","author":"Pouramir M.","year":"2011","journal-title":"Journal of Medicinal Plants Research"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2015.02.008"},{"key":"e_1_2_9_21_2","article-title":"Effects of Securigera securidaca (L.) Degen & Dorfl seed extract combined with glibenclamide on paraoxonase 1 activity, lipid profile and peroxidation, and cardiovascular risk indices in diabetic rats","volume":"10","author":"Alizadeh Fanalou S.","year":"2020","journal-title":"BioImpacts"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8394818"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-017-0656-3"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.253359"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112331"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.04.026"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.98"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-015-1181-7"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.04.021"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1078\/094471103321659933"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167125"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1507-0"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6014380"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2019.03.003"},{"key":"e_1_2_9_36_2","first-page":"172","article-title":"Association between markers of systemic inflammation, oxidative stress, lipid profiles, and insulin resistance in pregnant women","volume":"9","author":"Asemi Z.","year":"2013","journal-title":"ARYA Atheroscler"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.10.2299"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s194787"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00794-1"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.26538\/tjnpr\/v4i9.8"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1020"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6989963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/6989963.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/6989963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:06:46Z","timestamp":1735690006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/6989963"}},"subtitle":[],"editor":[{"given":"Krzysztof","family":"Siemianowicz","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/6989963"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6989963","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6989963"}}