{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:18:34Z","timestamp":1767169114571,"version":"build-2238731810"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hainan Medical and Health Research Project","award":["2001360101A2004"],"award-info":[{"award-number":["2001360101A2004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:p>\n                    Objective. To investigate the external application of traditional Chinese medicine in the prevention and treatment of nausea and vomiting caused by chemotherapy of non-small-cell lung cancer. Methods. This is a prospective trial. A total of 114 patients with non-small-cell lung cancer who were hospitalized in our hospital from October 2020 to March 2022 were selected and randomly divided into the research group and the control group at the ratio of 1\u2009:\u20091. The control group received chemotherapy\u2009+\u2009tropisetron 4\u2009mg intravenous drip 30 minutes before chemotherapy.\/day\u2009\u00d7\u20093 days. The research group received chemotherapy\u2009+\u2009intravenous infusion of tropisetron 4\u2009mg 30 minutes before chemotherapy, once a day for 3 days\u2009+\u2009external application of traditional Chinese medicine for 5 days. The therapeutic effects of the two groups of patients were compared. Results. After treatment, the serum creatinine, urea nitrogen, and endogenous creatinine in the research group were better than those in the control group (t\u2009=\u200915.943, 12.005, and 13.325;\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    , 0.005, and 0.005). After treatment, ALT and TBIL in the research group were superior to those in the control group (t\u2009=\u200911.583, 10.012, and 9.426;\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    , 0.002, and 0.001). After treatment, the physiological status, social\/family status, emotional status, and family status of the research group were significantly better than those in the control group (t\u2009=\u200916.274, 5.379, 5.142, and 8.153;\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.005<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    , 0.000, 0.002, and 0.001). After treatment, the ECOG score and KPS score (82.46\u2009\u00b1\u20094.61) of the research group were significantly different from those of the control group (t\u2009=\u200911.913 and 9.357;\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.035<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    and 0.001). The effective rate (\u03c72\u2009=\u200911.724;\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.000<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ) of the research group was higher but the incidence of adverse reaction (\u03c72\u2009=\u20094.294;\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ) was lower than that of the control group. Conclusion. External application of traditional Chinese medicine can significantly reduce nausea and vomiting caused by chemotherapy of non-small-cell lung cancer and can improve the patient\u2019s body and quality of life, which is worthy of clinical research and promotion.\n                  <\/jats:p>","DOI":"10.1155\/2022\/6992673","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T18:35:14Z","timestamp":1659638114000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["External Application of Traditional Chinese Medicine in the Prevention and Treatment of Nausea and Vomiting Caused by Chemotherapy of Non-Small-Cell Lung Cancer: A RCT Study"],"prefix":"10.1155","volume":"2022","author":[{"given":"Song-Jing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Hainan Provincial People\u2019s Hospital, Haikou 570311, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Hainan Provincial People\u2019s Hospital, Haikou 570311, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Jun","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Hainan Provincial People\u2019s Hospital, Haikou 570311, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Hainan Provincial People\u2019s Hospital, Haikou 570311, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-8152","authenticated-orcid":true,"given":"Jia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Hainan Provincial People\u2019s Hospital, Haikou 570311, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"S259","article-title":"Overview of chemotherapy-induced nausea and vomiting and evidence-based therapies","volume":"23","author":"N. Adel","year":"2017","journal-title":"American Journal of Managed Care"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1515442"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6054-x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4464-y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2015.16.15.6207"},{"issue":"1","key":"6","first-page":"49","article-title":"Naus\u00e9es et vomissements induits par la chimioth\u00e9rapie [Nausea and vomiting induced by chemotherapy]","volume":"69","author":"F. Scott\u00e9","year":"2019","journal-title":"Revue du Praticien"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-019-01001-1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017109"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007786.pub3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0816-z"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05611-w"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000348"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2020.101925"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/21548331.2015.1077095"}],"updated-by":[{"DOI":"10.1155\/2023\/9810509","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"record-id":"59949"},{"DOI":"10.1155\/2023\/9810509","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/6992673.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/6992673.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/6992673.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T18:35:20Z","timestamp":1659638120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/6992673\/"}},"subtitle":[],"editor":[{"given":"Tian jiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":14,"alternative-id":["6992673","6992673"],"URL":"https:\/\/doi.org\/10.1155\/2022\/6992673","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,4]]}}}