{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:02:13Z","timestamp":1778212933937,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":188,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhenghai District Science and Technology Bureau","award":["2017S203"],"award-info":[{"award-number":["2017S203"]}]},{"name":"Zhenghai District Science and Technology Bureau","award":["2018S1001"],"award-info":[{"award-number":["2018S1001"]}]},{"name":"Public Welfare Project in Zhenghai District","award":["2017S203"],"award-info":[{"award-number":["2017S203"]}]},{"name":"Public Welfare Project in Zhenghai District","award":["2018S1001"],"award-info":[{"award-number":["2018S1001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease characterized by the excessive accumulation of hepatocyte fat and steatosis in the absence of alcohol or any other clear contributing factors to liver injury. NAFLD has been confirmed to be closely associated with obesity, insulin resistance, and dyslipidemia. Genetic polymorphism studies have shown the relations between the apolipoprotein A5 gene (APOA5) and NAFLD. However, the association between the serum ApoA5 level and NAFLD remains unclear. Between September 2018 and August 2019, adults who attended the hospital\u2010based health checkup center were enrolled in this study. Anthropometric examination, laboratory investigations on fasting blood, and abdominal ultrasonography were performed. The serum ApoA5 level was determined by enzyme\u2010linked immunosorbent assay. A total of 517 eligible participants (317 females and 200 males) were involved in this study, with a mean age of 54.7\u2009\u00b1\u200916.7 years. The mean ApoA5 concentration was 28.8\u2009\u00b1\u20094.7\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, among which the males had higher concentration levels than females (29.3\u2009\u00b1\u20094.5 vs. 28.5\u2009\u00b1\u20094.7\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, <jats:italic>P<\/jats:italic> = 0.04). Serum ApoA5 level was not significantly correlated with NAFLD or metabolic profiles. However, the prevalence rate of hypertriglyceridemia (triglyceride\u2009\u2265\u20091.7\u2009mmol\/L) showed a significant inverted \u201cU\u201d\u2010shaped trend in individuals with the serum ApoA5 level of quartile one to quartile four after adjusting the confounding factors. Moreover, individuals with higher serum ApoA5 levels were also more likely to suffer from hyperglycemia. The ApoA5 levels and the prevalence of hypertriglyceridemia are in an inverted \u201cU\u2010shaped\u201d correlation, but there is no significant difference between ApoA5 levels, NAFLD, and metabolic syndrome.<\/jats:p>","DOI":"10.1155\/2022\/7015528","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T22:20:18Z","timestamp":1657318818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Serum Apolipoprotein A5 Concentration with Nonalcoholic Fatty Liver Disease in Ningbo, China"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueping","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongyi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-6376","authenticated-orcid":false,"given":"Qunfen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0000000000000116"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13857"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14709"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(14)70032-4"},{"key":"e_1_2_10_5_2","first-page":"9","article-title":"Non alcoholic fatty liver disease and metabolic syndrome","volume":"13","author":"Paschos P.","year":"2009","journal-title":"Hippokratia"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.36290\/vnl.2019.098"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12349"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10449"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064852"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.05.003"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.040824"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m106888200"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29911"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.d119000103"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7461"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m403240200"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000186189.26141.12"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.222224"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2018.04.004"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.169404"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.12.002"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.53738\/revmed.2020.16.687.0586"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.14712\/fb2019065040188"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020016"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.12.035"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.d500018-jlr200"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.07.014"}],"container-title":["Contrast Media &amp; 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