{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:22:49Z","timestamp":1757456569623,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"publisher","award":["SKL-HIDCA-2020-43"],"award-info":[{"award-number":["SKL-HIDCA-2020-43"]}],"id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2022,2,18]]},"abstract":"<jats:p>Diabetes mellitus (DM) has become a major medical and health problem in my country and even the world. Doctors and patients have gradually realized that a new type of metabolic surgery is a way to treat diabetes. The operation is relatively simple, and the effect of the operation is no less than that of the gastric shunt. The initial hypothesis could not fully explain the blood pressure and blood sugar reduction mechanism in waist and abdominal surgery. According to requirements, they were divided into the sleeve gastrectomy group (SG group, n\u2009=\u200910) and sham operation group (SS group, n\u2009=\u200910), and corresponding measures were taken. Observe their weight changes; perform an oral glucose tolerance test (GB) before surgery and at 2, 8, and 16 weeks after surgery to evaluate the effect of surgery on improving the glucose metabolism. The postoperative GLP-1 specificity curve was detected in the two groups of patients; the immunohistochemical method was used to detect the postoperative changes of the digestive tract l cells in the two groups; RT-PCR was used to detect the mRNA transcription level of the digestive tract GLP-1 receptor. The bodyweight was significantly different 4 weeks after the operation. Food intake and bodyweight were not significantly different between the SG and SS groups. FBG: one week after operation, the SG group was significantly smaller than the SS group. The SS group was significantly lower than the SG group at 12 weeks after operation, and the SS group was significantly lower than the SG group at 14 weeks after operation. The transcription levels of c-kit mRNA and SCF mRNA in jejunum and ileum tissues are significantly different: the transcription levels of c-kit mRNA and SCF mRNA in the SG group are higher than those in the SS group, jejunum and ileum in the SG group. The number of cell 1 was significantly greater than that of the SS group. Sleeve gastrectomy can improve the regulation of the glucose metabolism in diabetic rats. The increase in small bowel motility may be related to the increase in ICC cells, intestinal cells, and GLP after gastric sleeve resection. The increase is in -1R and faster insoluble CHM in bowel motility. It has better contact with cell 1 and GLP-1R and stimulates cell 1 to secrete GLP-1.<\/jats:p>","DOI":"10.1155\/2022\/7027777","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T21:05:05Z","timestamp":1645218305000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Explore the Link between the Improvement of Metabolic Indicators in Diabetic Rats with Sleeve Gastrectomy and Changes in the Composition of Intestinal Flora"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jingjing","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apaer","family":"Shadiker","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shensen","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-3318","authenticated-orcid":true,"given":"Xinling","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"9","key":"1","first-page":"1556","article-title":"Correlation of patient health promotion behavior, stress response, social support and weight loss effects after laparoscopic gastric cuhorectomy","volume":"35","author":"L. Zhang","year":"2021","journal-title":"Nursing Research"},{"issue":"4","key":"2","first-page":"405","article-title":"Analysis of 7 cases of laparoscopic surgery for pathological sleeve gastrectomy combined with abdominal wall hernia in the same period","volume":"41","author":"L. Wu","year":"2021","journal-title":"Chinese Journal of Practical Surgery"},{"issue":"3","key":"3","first-page":"13","article-title":"Clinical paper of laparoscopic sleeve gastrectomy for sleeve gastrectomy combined with type 2 diabetes mellitus","volume":"41","author":"X. Dong","year":"2021","journal-title":"Clinical Medicine"},{"issue":"3","key":"4","first-page":"172","article-title":"Recent efficacy of laparoscopic sleeve gastrectomy combined with esophageal hiatal hernia repair in the treatment of sleeve gastrectomy combined with obstructive sleep apnea syndrome","volume":"26","author":"E. Aikbye","year":"2021","journal-title":"Journal of Laparoscopic Surgery"},{"issue":"3","key":"5","first-page":"161","article-title":"Comparative paper of the effects of sleeve gastrectomy and esophageal duodenal anastomosis with total gastrectomy on glucose metabolism in sleeve gastrectomy with type 2 diabetic rat model","volume":"26","author":"X. Qi","year":"2021","journal-title":"Journal of Laparoscopic Surgery"},{"issue":"3","key":"6","first-page":"165","article-title":"Analysis of the efficacy and related factors of laparoscopic sleeve gastrectomy for pathological sleeve gastrectomy combined with type 2 diabetes mellitus","volume":"26","author":"X. Wang","year":"2021","journal-title":"Journal of Laparoscopic Surgery"},{"issue":"3","key":"7","first-page":"177","article-title":"Effect of laparoscopic sleeve gastrectomy on serum uric acid levels in patients with sleeve gastrectomy","volume":"26","author":"K. Irpanjiang","year":"2021","journal-title":"Journal of Laparoscopic Surgery"},{"issue":"8","key":"8","first-page":"165","article-title":"Peroperative dietary guidance for sleeve gastrectomy in patients with sleeve gastrectomy","volume":"37","author":"M. Zhao","year":"2021","journal-title":"Chinese Community Physician"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1177\/0013161x05278189"},{"issue":"3","key":"10","first-page":"273","article-title":"Progress in the weight-loss metabolic surgery","volume":"49","author":"S. Li","year":"2021","journal-title":"Chinese Journal for Clinicians"},{"issue":"1","key":"11","first-page":"1","article-title":"Cause and prevention strategies of anemia after sleeve gastrectomy and Roux-en-Y gastric bypass surgery","volume":"16","author":"Z. Dong","year":"2021","journal-title":"Minimally Invasive Medicine"},{"issue":"1","key":"12","first-page":"113","article-title":"Application of digital health management in the follow-up of patients with sleeve gastrectomy","volume":"38","author":"L. Li","year":"2021","journal-title":"Chinese Journal of Social Medicine"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2021.100344"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102369"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.115975"},{"issue":"8","key":"16","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1007\/s11695-021-05437-3","article-title":"Long-term effects of laparoscopic sleeve gastrectomy: what are the results beyond 10 years?","volume":"31","author":"M. Kraljevi\u0107","year":"2021","journal-title":"Obesity Surgery"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100248"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.techfore.2021.120820"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3934\/mbe.2021320"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00874"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.2317\/0022-8567-93.4.267"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.105092"},{"issue":"1","key":"23","first-page":"124","article-title":"Comment on the article addressing spirituality, religiosity and nationalism from the perspective of public and global mental health","volume":"32","author":"E. Zerem","year":"2020","journal-title":"Psychiatria Danubina"},{"issue":"2","key":"24","first-page":"307","article-title":"COVID-19, mentally ill and mental health workers","volume":"32","author":"A. Cioffi","year":"2020","journal-title":"Psychiatria Danubina"}],"container-title":["Journal of Healthcare Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/7027777.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/7027777.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/7027777.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T21:05:20Z","timestamp":1645218320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jhe\/2022\/7027777\/"}},"subtitle":[],"editor":[{"given":"Bhagyaveni","family":"M.A","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":24,"alternative-id":["7027777","7027777"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7027777","relation":{},"ISSN":["2040-2309","2040-2295"],"issn-type":[{"type":"electronic","value":"2040-2309"},{"type":"print","value":"2040-2295"}],"subject":[],"published":{"date-parts":[[2022,2,18]]}}}