{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:21:31Z","timestamp":1792002091398,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":191,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015850","name":"Digestive Medical Coordinated Development Center of Beijing Hospitals Authority","doi-asserted-by":"publisher","award":["XXT26"],"award-info":[{"award-number":["XXT26"]}],"id":[{"id":"10.13039\/501100015850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2301800"],"award-info":[{"award-number":["2021YFC2301800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Currently, there are few studies on the effect of prophylactic anti\u2010hepatitis B virus (HBV) therapy (AVT) for mother\u2010to\u2010child transmission during pregnancy on postpartum hepatitis flare (PHF) and the risk factors for postpartum hepatitis flare in women with chronic hepatitis B infection. <jats:italic>Aim<\/jats:italic>: To analyze the effect of AVT on the postpartum hepatitis flare and risk factors related to postpartum hepatitis flare. <jats:italic>Methods<\/jats:italic>: This study retrospectively enrolled hepatitis B surface antigen (HBsAg)\u2010positive and hepatitis B e antigen (HBeAg)\u2010positive women with HBV DNA \u2265 10<jats:sup>6<\/jats:sup>\u2009 IU\/mL. Six hundred fourteen pregnant women were included: 444 in the anti\u2010HBV therapy group (T\u2010G) and 170 in the control group (C\u2010G). To analyze the risk factors, women with alanine aminotransferase (ALT) flare (ALT &gt; 40\u2009U\/L) were assigned to the PHF group (PHF\u2010G, <jats:italic>n<\/jats:italic> = 355), and all the others were assigned to a non\u2010PHF group (NPHF\u2010G, <jats:italic>n<\/jats:italic> = 259). <jats:italic>Results<\/jats:italic>: At 6 weeks postpartum, ALT and AST levels were higher, and ALB levels were lower in the C\u2010G than those in T\u2010G (<jats:italic>P<\/jats:italic> &lt; 0.05). Also, ALT (at baseline, pregnancy 32nd and 36th, intrapartum), AST (at pregnancy 32nd and 36th week, and intrapartum), HBcAb (at baseline, intrapartum), and HBV DNA (at intrapartum) of PHF\u2010G were significantly higher than those of NPHF\u2010G (<jats:italic>P<\/jats:italic> &lt; 0.05). Multivariate analysis showed that ALT (OR = 1.067, <jats:italic>P<\/jats:italic> &lt; 0.001) and HBcAb (OR = 1.213, <jats:italic>P<\/jats:italic> \u2264 0.001) in pregnant women were risk factors for PHF. The prophylactic anti\u2010HBV for the prevention of perinatal HBV transmission (OR = 0.357, <jats:italic>P<\/jats:italic> &lt; 0.001) was the protective factor for PHF. <jats:italic>Conclusion<\/jats:italic>: Pregnant women with prophylactic anti\u2010HBV during the third trimester of pregnancy had a lower incidence of postpartum hepatitis flare, especially a lower risk of serious hepatitis flare. ALT and HBcAb in pregnant women were risk factors for PHF. Women infected with HBV should be closely monitored ALT during pregnancy and postpartum.<\/jats:p>","DOI":"10.1155\/2022\/7046955","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T22:50:16Z","timestamp":1657579816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antiviral Therapy for Prevention of Perinatal Hepatitis B Virus Transmission Reduces the Incidence of Postpartum Hepatitis 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