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Mortality caused by septic shock remains in a high rate even though antibiotic treatment works effectively. In this study, we treat THP-1 cells with 1\u2009ug\/mL LPS (lipopolysaccharide) and add paeoniflorin or LR-12 inhibitor. TREM-1 (triggering receptor expressed on myeloid cells-1), IL-6, IL-1\u03b2, and TNF-\u03b1 (tumour necrosis factor alpha (a)-cachectin) were detected by ELISA and qRT-PCR, and western blotting is performed to detect related proteins in the NF-\u03baB signaling pathway. As a result, paeoniflorin can significantly reduce the production of LPS-stimulated TREM-1 as well as inflammatory factors and attenuate the phosphorylation of NF-\u03baB signaling pathway-related factors, such as p65 and I\u03baB\u03b1. At the same time, the combined effect of paeoniflorin and LR-12 is more significant. The results of this study solidly prove that paeoniflorin plays a role in inhibiting TREM-1-mediated inflammation and the NF-\u03baB pathway could be a potential mechanism of action.<\/jats:p>","DOI":"10.1155\/2022\/7051643","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T23:20:08Z","timestamp":1650324008000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Paeoniflorin Attenuated TREM-1-Mediated Inflammation in THP-1 Cells"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-5319","authenticated-orcid":true,"given":"Li","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Critical Medicine, Shenzhen Baoan Shiyan People\u2019s Hospital, Shenzhen 5515108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Suzhou Medical College, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra021333"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000194725.48928.3a"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.5603\/AIT.2015.0002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000026"},{"key":"5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1172\/JCI200319523","article-title":"The enigma of sepsis","volume":"112","author":"N. 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