{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:56:53Z","timestamp":1784591813541,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,1,20]]},"abstract":"<jats:p>Chagas disease (CD) is an important parasitic disease caused by Trypanosoma cruzi. Interleukin-32 (IL-32) plays an important role in inflammation and in the development of Th1\/Th17 acquired immune responses. We evaluated the influence of IL-32\u03b3 on the immune response profile, pathogenesis of myocarditis in acute experimental CD, and control of the disease. For this, C57BL\/6 wild-type (WT) and IL-32\u03b3Tg mice were infected subcutaneously with 1,000 forms of Colombian strain of T. cruzi. In the histopathological analyzes, T. cruzi nests, myocarditis, and collagen were quantified in cardiac tissue. Cytokine productions (IL-32, IFN-\u03b3, TNF-\u03b1, IL-10, and IL-17) were measured in cardiac homogenate by ELISA. The IL-32\u03b3Tg mice showed a better control of parasitemia and T. cruzi nests in the heart than WT mice. Infected-WT and -IL-32\u03b3Tg mice showed similar levels of IFN-\u03b3, TNF-\u03b1, and IL-17, but IL-10 was significantly higher expressed in IL-32\u03b3Tg than in WT mice. The cytokine profile found in IL-32\u03b3Tg animals contributed to body weight maintenance, parasitemia control, and survival. Our results indicate that the presence of human IL-32\u03b3 in mice infected with the Colombian strain of T. cruzi is important for infection control during the acute phase of Chagas disease.<\/jats:p>","DOI":"10.1155\/2022\/7070301","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T01:50:05Z","timestamp":1642729805000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Interleukin-32\u03b3 in the Control of Acute Experimental Chagas Disease"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-548X","authenticated-orcid":true,"given":"Yarlla L. L.","family":"Braga","sequence":"first","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-5112","authenticated-orcid":true,"given":"Jos\u00e9 R. C.","family":"Neto","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-0400","authenticated-orcid":true,"given":"Arthur W. F.","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel V. T.","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-7621","authenticated-orcid":true,"given":"Marcos V.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara R. N.","family":"Celes","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton A. P.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A. B.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"},{"name":"Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-3414","authenticated-orcid":true,"given":"F\u00e1tima","family":"Ribeiro-Dias","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo S.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-7788","authenticated-orcid":true,"given":"Juliana R.","family":"Machado","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia, GO, Brazil"},{"name":"Departamento de Patologia, Gen\u00e9tica e Evolu\u00e7\u00e3o, Instituto de Ci\u00eancias Biol\u00f3gicas e Naturais, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","article-title":"Weekly epidemiological record","volume":"91","author":"WHO","year":"2016","journal-title":"Weekly Epidemiological Record"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020117-043711"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/295394"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1491-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01108.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.12.4862-4867.1995"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.1.128-134.1996"},{"key":"8","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.4049\/jimmunol.159.12.6131","article-title":"Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania species membranes trigger nitric oxide synthesis as well as microbicidal activity in IFN-gamma-primed macrophages","volume":"159","author":"M. M. Camargo","year":"1997","journal-title":"The Journal of Immunology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.5493\/wjem.v3.i1.1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.3.539"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.1.169"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.12.003"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02917.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.4RU0416-175RR"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.10.003"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03025.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511233103"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901913"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424302112"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.05.009"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0366-z"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015418107"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00796-17"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-017-2268-4"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-249"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761990000100003"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003464"},{"key":"28","first-page":"368","article-title":"Doen\u00e7a de chagas: manual para experimenta\u00e7\u00e3o animal","volume-title":"Antropologia e Sa\u00fade collection","author":"T. C. A. Jorge","year":"2000"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204895"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.23.1763"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003010"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftv082"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/648715"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000900025"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63019-2"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1590\/s0037-86822009000200015"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.025"},{"key":"38","article-title":"Cl\u00ednica e terap\u00eautica da doen\u00e7a de Chagas: uma abordagem pr\u00e1tica para o cl\u00ednico geral","volume":"486","author":"E. R. Lopes","year":"1997","journal-title":"Rio de Janeiro: Editora FIOCRUZ"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002139"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/178947"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1186\/ar4089"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002306"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1177"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4AB0219-071R"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900047"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000604"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1086\/596061"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001630"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis724"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/7070301.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/7070301.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/7070301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T23:12:52Z","timestamp":1674515572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2022\/7070301\/"}},"subtitle":[],"editor":[{"given":"Syed Sameer","family":"Aga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":49,"alternative-id":["7070301","7070301"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7070301","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"value":"2314-7156","type":"electronic"},{"value":"2314-8861","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,20]]}}}