{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:56:00Z","timestamp":1792806960070,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2019HXFH042"],"award-info":[{"award-number":["2019HXFH042"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2020YFS0147"],"award-info":[{"award-number":["2020YFS0147"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["19PJ098"],"award-info":[{"award-number":["19PJ098"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2019HXFH042"],"award-info":[{"award-number":["2019HXFH042"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFS0147"],"award-info":[{"award-number":["2020YFS0147"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["19PJ098"],"award-info":[{"award-number":["19PJ098"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["2019HXFH042"],"award-info":[{"award-number":["2019HXFH042"]}],"id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFS0147"],"award-info":[{"award-number":["2020YFS0147"]}],"id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["19PJ098"],"award-info":[{"award-number":["19PJ098"]}],"id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:p>Adenosine deaminase 2 (ADA2) is reported as a novel diagnostic biomarker for tuberculous pleural effusion (TPE) in many studies. This meta-analysis was conducted to systematically evaluate the general diagnostic performance of pleural ADA2 in TPE. After searching for relevant studies that investigated the diagnostic performance of pleural ADA2 in TPE in several databases, we assessed and selected eligible studies to calculate pooled parameters by STATA 16.0 software. A final set of thirteen studies entirely met the inclusion standards and were used to calculate pooled parameters in our meta-analysis. Among them, there were nine English studies and four Chinese studies. The pooled parameters of pleural ADA2 in diagnosing TPE were summarized as follows: sensitivity, 0.91 (95% CI: 0.86\u20130.95); specificity, 0.93 (95% CI: 0.92\u20130.95); positive likelihood ratio, 13.9 (95% CI: 10.6\u201318.3); negative likelihood ratio, 0.09 (95% CI:0.06\u20130.16); diagnostic odds ratio, 147 (95% CI: 76\u2013284); and the area under the curve, 0.95 (95% CI: 0.93\u20130.97). Pleural ADA2 is a reliable indicator with excellent accuracy in TPE diagnosis. However, we need to combine pleural ADA2 with diverse examinations to diagnose TPE in clinical practice.<\/jats:p>","DOI":"10.1155\/2022\/7078652","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T19:50:16Z","timestamp":1662839416000},"page":"1-10","source":"Crossref","is-referenced-by-count":14,"title":["The Value of Adenosine Deaminase 2 in the Detection of Tuberculous Pleural Effusion: A Meta-Analysis and Systematic Review"],"prefix":"10.1155","volume":"2022","author":[{"given":"Tingting","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueru","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, West China Hospital of Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-1792","authenticated-orcid":true,"given":"Yongchun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-9955","authenticated-orcid":true,"given":"Dajiang","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"8","key":"1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237753","article-title":"The epidemiology of extrapulmonary tuberculosis in China: a large-scale multi-center observational study","volume":"15","author":"W. Kang","year":"2020","journal-title":"PLoS One"},{"issue":"6","key":"2","first-page":"981","article-title":"Tuberculous pleural effusions: advances and controversies","volume":"7","author":"M. J. Vorster","year":"2015","journal-title":"Journal of Thoracic Disease"},{"issue":"21","key":"3","first-page":"377","article-title":"Pleural effusion in adults-etiology, diagnosis, and treatment","volume":"116","author":"B. Jany","year":"2019","journal-title":"Deutsches Arzteblatt International"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.1098535"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200007000-00002"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0530-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.05.015"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2143(96)90182-1"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09040632"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmyco.2014.11.035"},{"issue":"10","key":"11","first-page":"CR708","article-title":"Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis","volume":"8","author":"N. A. Andreasyan","year":"2002","journal-title":"Medical Science Monitor"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5930951"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1177\/0272989X09353452","article-title":"Bivariate random effects meta-analysis of diagnostic studies using generalized linear mixed models","volume":"30","author":"H. Chu","year":"2010","journal-title":"Medical Decision Making"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.022"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.016"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09040747"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2000.00270.x"},{"key":"20","article-title":"Clinical investigation on diagnostic value of interferon-\u03b3, interleukin-12 and adenosine deaminase isoenzyme for tuberculous pleurisy","volume":"118","author":"G. C. Tianrui-Xue","year":"2005","journal-title":"Chinese Medical Journal"},{"key":"21","article-title":"Diagnostic value of adnnosine deaminase isoznyme (ADA2) and total ADA in tuberculous pleural effusion","volume":"4","author":"Z. Mohammadtaheri","year":"2005","journal-title":"Tanaffos"},{"issue":"5","key":"22","first-page":"61","article-title":"Adenosine deaminase isoenzymes estimation - as a diagnostic tool for tuberculous pleural effusions","volume":"2","author":"N. K. Nalla","year":"2009","journal-title":"Asian Pacific Journal of Tropical Medicine"},{"issue":"2","key":"23","first-page":"214","article-title":"The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions","volume":"13","author":"A. E. Zemlin","year":"2009","journal-title":"International Journal of Tuberculosis & Lung Disease"},{"issue":"20","key":"24","first-page":"2","article-title":"Diagnostic value of adenosine deaminase isoenzyems in tuberculous pleurisy and carcinomatous pleurisy","volume":"6","author":"F. Z. Li","year":"2009","journal-title":"Clinics in Laboratory Medicine"},{"issue":"1","key":"25","first-page":"1","article-title":"Activities of adenine deaminase (ADA) and isoenzyme ADA2 in the pleural effusion from patients with TB pleurisy","volume":"23","author":"W. S. Shih","year":"2011","journal-title":"Journal of Biomedical & Laboratory Sciences"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.05.009"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-9-118"},{"key":"28","doi-asserted-by":"crossref","DOI":"10.1186\/2049-6958-9-12","article-title":"Diagnostic utility of serum and pleural levels of adenosine deaminase 1\u20132, and interferon-\u03b3 in the diagnosis of pleural tuberculosis","volume":"9","author":"S. Yurt","year":"2014","journal-title":"Multidisciplinary Respiratory Medicine"},{"issue":"4","key":"29","first-page":"4","article-title":"Differential diagnosis value of pleural effusion ADA, ADA2 and ACE levels in tuberculous and malignant pleural effusion","volume":"35","author":"Z. B. Wang Xy","year":"2020","journal-title":"Journal of Modern Laboratory Medicine"},{"issue":"4","key":"30","article-title":"Diagnostic value of ADA and ADA isozyme in tuberculous pleurisy","volume":"2","author":"Z. Y. Zhang Zj","year":"2020","journal-title":"Hunan Normal University (Medical Science)"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/srep19785"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1136\/eb-2013-101243"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1836-8"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.98811"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2009.10.012"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0236"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.11.109"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.02.024"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.00179.x"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7458.168"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.2174\/092986710791233652"},{"issue":"12","key":"42","first-page":"731","article-title":"Adenosine deaminase 2 in the diagnosis of tuberculous pleuritis","volume":"80","author":"N. Inase","year":"2005","journal-title":"Kekkaku: Tuberculosis"},{"key":"43","first-page":"38","article-title":"Diagnostic characteristics of adenosine deaminase test in Byelorussian patients with tuberculous pleurisy","volume":"8","author":"A. D. Taganovich","year":"2008","journal-title":"Problemy tuberkuleza i boleznei legkikh"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2022\/7078652.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2022\/7078652.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2022\/7078652.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T19:50:34Z","timestamp":1662839434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crj\/2022\/7078652\/"}},"subtitle":[],"editor":[{"given":"Youfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,10]]},"references-count":43,"alternative-id":["7078652","7078652"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7078652","relation":{},"ISSN":["1916-7245","1198-2241"],"issn-type":[{"value":"1916-7245","type":"electronic"},{"value":"1198-2241","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,10]]}}}