{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:19:26Z","timestamp":1778051966190,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007846","name":"Yunnan Provincial Department of Education","doi-asserted-by":"publisher","award":["2020Y0202"],"award-info":[{"award-number":["2020Y0202"]}],"id":[{"id":"10.13039\/501100007846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,1,12]]},"abstract":"<jats:p>Background. Using network pharmacology and molecular docking, this study aimed to explore the active pharmaceutical ingredients (APIs) and molecular mechanism of Qinshi Simiao San (QSSMS) in the treatment of chronic prostatitis (CP) and verify our findings in the rat model. Methods. The APIs of QSSMS and the common targets of QSSMS and CP were screened from the TCMSP database. The STRING database and Cytoscape software were used to construct the network graph. The enriched GO and KEGG pathways were displayed by David software and R software. Molecular docking was performed to visualize key components and target genes. In addition, the rats model of CP was established to verify the molecular mechanism of QSSMS. Results. Network pharmacology showed that the APIs of QSSMS mainly included quercetin, kaempferol, formononetin, isorhamnetin, and calycosin. QSSMS alleviated CP mainly through the negative regulation of the apoptotic process, oxidation-reduction process, inflammatory response, and immune response. Molecular docking showed that the APIs could bind to the corresponding targets. QSSMS repaired the pathological damage of prostate tissue, upregulated the expression of oxidative stress scavenging enzymes CAT and SOD, and downregulated the peroxidative product MDA, inflammatory factors IL-1\u03b2, IL-6, TNF-\u03b1, COX-2, PGE2, and NGF, and immune factors IgG and SIgA. Conclusion. The APIs in QSSMS may inhibit inflammation in the rat CP model by regulating immune and oxidative stress.<\/jats:p>","DOI":"10.1155\/2022\/7098121","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T18:35:08Z","timestamp":1642012508000},"page":"1-13","source":"Crossref","is-referenced-by-count":4,"title":["Network Pharmacology and Molecular Docking Verify the Mechanism of Qinshi Simiao San in Treating Chronic Prostatitis in the Rat Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-9256","authenticated-orcid":true,"given":"Chenxi","family":"Li","sequence":"first","affiliation":[{"name":"Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-0523","authenticated-orcid":true,"given":"Xuyao","family":"Lin","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingrui","family":"Li","sequence":"additional","affiliation":[{"name":"Aerospace Central Hospital, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoming","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipeng","family":"Fan","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[{"name":"Shenzhen Baoan Hospital of Traditional Chinese Medicine (Group), Shenzhen 518133, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-7944","authenticated-orcid":true,"given":"Zhuojun","family":"Yuan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-8931","authenticated-orcid":true,"given":"Guozheng","family":"Qin","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming 650021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28380"},{"issue":"12","key":"2","article-title":"Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis","volume":"79","author":"G. 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