{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:16:25Z","timestamp":1758708985203,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":210,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>This paper aims to investigate the clinical and laboratory test characteristics of patients with anti\u2010MDA5 antibody\u2010positive PM\/DM by analyzing the clinical characteristics, laboratory test results, and 1\u2010year survival rate of patients with anti\u2010MDA5 antibody\u2010positive PM\/DM in polymyositis (PM) and dermatomyositis (DM). To further investigate the impact of positive anti\u2010MDA5 antibodies on the prognosis of PM\/DM patients. According to the anti\u2010MDA5 antibody test results, 18 cases with positive anti\u2010MDA5 antibodies were in the positive group and 46 cases with negative anti\u2010MDA5 antibodies were in the negative group. The clinical manifestations, laboratory tests, treatment protocols, and prognostic risk factors were collected for both groups. The chi\u2010square test, Mann\u2013Whitney method, Fisher test, <jats:italic>t<\/jats:italic>\u2010test, Kaplan\u2013Meier method, and Log\u2010rank test were used for statistical analysis. Anti\u2010MDA5 antibody positivity was more common in patients with DM\/CADM. With no statistically significant differences in age and sex ratio between the two groups, The differences in erythrocyte sedimentation rate (ESR), ferritin (Fer), and creatine kinase (CK) levels in the positive group were statistically significant compared with the negative group. Clinically, the positive group was more prone to arthralgia, skin rash, and interstitial pneumonia.<\/jats:p>","DOI":"10.1155\/2022\/7102480","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T23:35:07Z","timestamp":1659224107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Features of Dermatomyositis\/Polymyositis with Anti\u2010MDA5 Antibody Positivity"],"prefix":"10.1155","volume":"2022","author":[{"given":"Qiuhe","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-272X","authenticated-orcid":false,"given":"Long","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_1_2","DOI":"10.1016\/s0140-6736(03)14368-1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_2_2","DOI":"10.1016\/j.nmd.2004.02.006"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_2","DOI":"10.1016\/j.autrev.2018.10.004"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_2","DOI":"10.1056\/nejm197502132920706"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_2","DOI":"10.1067\/mjd.2002.120621"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_2","DOI":"10.1002\/art.21023"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_2","DOI":"10.1002\/art.24621"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_2","DOI":"10.1007\/s10067-015-2935-9"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_2","DOI":"10.1186\/ar4600"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_2","DOI":"10.2152\/jmi.65.251"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_2","DOI":"10.18632\/oncotarget.15716"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_2","DOI":"10.1016\/j.resinv.2019.05.003"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_2","DOI":"10.2169\/internalmedicine.49.2889"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_2","DOI":"10.1016\/j.jbspin.2007.06.016"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_2","DOI":"10.1002\/jcla.21908"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_2","DOI":"10.1371\/journal.pone.0190411"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_2","DOI":"10.5606\/archrheumatol.2018.6419"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_2","DOI":"10.1371\/journal.pone.0098824"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_2","DOI":"10.1183\/09031936.06.00038806"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_2","DOI":"10.1093\/rheumatology\/keq149"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_2","DOI":"10.1002\/acr.21985"},{"doi-asserted-by":"publisher","key":"e_1_2_7_22_2","DOI":"10.1155\/2014\/290797"},{"doi-asserted-by":"publisher","key":"e_1_2_7_23_2","DOI":"10.18926\/AMO\/55311"},{"doi-asserted-by":"publisher","key":"e_1_2_7_24_2","DOI":"10.1080\/14397595.2017.1318468"},{"doi-asserted-by":"publisher","key":"e_1_2_7_25_2","DOI":"10.1093\/rheumatology\/keq073"},{"doi-asserted-by":"publisher","key":"e_1_2_7_26_2","DOI":"10.1002\/art.21240"},{"key":"e_1_2_7_27_2","first-page":"1527","article-title":"Corticosteroid resistant interstitial pneumonitis in dermatomyositis\/polymyositis: prediction and treatment with cyclosporine","volume":"26","author":"Nawata Y.","year":"1999","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_7_28_2","first-page":"1719","article-title":"Combination therapy with corticosteroids, cyclosporin A, and intravenous pulse cyclophosphamide for acute\/subacute interstitial pneumonia in patients with dermatomyositis","volume":"32","author":"Kameda H.","year":"2005","journal-title":"Journal of Rheumatology"},{"doi-asserted-by":"publisher","key":"e_1_2_7_29_2","DOI":"10.1007\/s11926-012-0246-6"}],"container-title":["Contrast Media &amp; 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