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Previous studies have indicated the antiapoptotic, antioxidative stress, and anti\u2010inflammatory effects of naringin. It can improve many common diseases, including fibrosis or hepatotoxicity, cardiovascular disease, and diabetes. Acetaminophen (APAP) is a frequently used painkiller, and hepatotoxic side effects limit its use. The purpose of the current examination is to find the impact of naringin on APAP\u2010induced hepatic injury. Firstly, we pretreated mice model groups with naringin. Then, the liver injury model was established by injecting intraperitoneally into mice with APAP. After the mice were euthanized, we obtained serum and liver tissue samples from the mice. Finally, these samples were analyzed using a metabolomics approach to find the underlying mechanism of the effects of naringin on APAP\u2010induced liver injury and provide a new treatment strategy for APAP\u2010induced liver injury. Our data indicate that naringin significantly improves APAP\u2010induced liver injury in mice and reduces the expression levels of liver injury markers in a dose\u2010dependent manner. Furthermore, analysis of differential metabolites in mice with liver injury showed that naringin reduced APAP\u2010induced hepatotoxicity due to reversing multiple metabolite expression levels and the rescue of energy, amino acid, and purine metabolism.<\/jats:p>","DOI":"10.1155\/2022\/7138194","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T23:05:07Z","timestamp":1663369507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploration of the Protective Mechanism of Naringin in the Acetaminophen\u2010Induced Hepatic Injury by 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