{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:14:33Z","timestamp":1793150073167,"version":"4.5.0"},"reference-count":142,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81822049"],"award-info":[{"award-number":["81822049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174364"],"award-info":[{"award-number":["82174364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Doxorubicin (DOX) is an anthracycline chemotherapy drug, which is indispensable in antitumor therapy. However, its subsequent induction of cardiovascular disease (CVD) has become the primary cause of mortality in cancer survivors. Accumulating evidence has demonstrated that cardiac mitochondrial bioenergetics changes have become a significant marker for doxorubicin\u2010induced cardiotoxicity (DIC). Here, we mainly summarize the related mechanisms of DOX\u2010induced cardiac mitochondrial bioenergetics disorders reported in recent years, including mitochondrial substrate metabolism, the mitochondrial respiratory chain, myocardial ATP storage and utilization, and other mechanisms affecting mitochondrial bioenergetics. In addition, intervention for DOX\u2010induced cardiac mitochondrial bioenergetics disorders using chemical drugs and traditional herbal medicine is also summarized, which will provide a comprehensive process to study and develop more appropriate therapeutic strategies for DIC.<\/jats:p>","DOI":"10.1155\/2022\/7176282","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T22:50:26Z","timestamp":1665787826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Mechanisms and Drug Intervention for Doxorubicin\u2010Induced Cardiotoxicity Based on Mitochondrial Bioenergetics"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-7040","authenticated-orcid":false,"given":"Guanjing","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-6196","authenticated-orcid":false,"given":"Nannan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-1339","authenticated-orcid":false,"given":"Weili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianbin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-9517","authenticated-orcid":false,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1689"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw604"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340311799960645"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11407"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03614-x"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-020-09576-4"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.10.043"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa017"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5179468"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2018.08.003"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.09.016"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.4.13.2210154"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.12.010"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215992"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep25333"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0044-6"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.570421"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12104"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.191122"},{"key":"e_1_2_11_20_2","first-page":"41","article-title":"Cardioprotective effect of lipistat against doxorubicin induced myocardial toxicity in albino rats","volume":"47","author":"Koti B. C.","year":"2009","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_11_21_2","first-page":"727","article-title":"Lipid lowering: an important factor in preventing adriamycin-induced heart failure","volume":"150","author":"Iliskovic N.","year":"1997","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-215-44122"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308537"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.04.011"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs309"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7595374"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0797-1"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.11.019"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.9.1756"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1493"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-303843"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00294.2015"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12095-y"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000057988.62605.13"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12176"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(99)00113-4"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006845120287"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(02)00612-0"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.06.009"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00259.x"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17797-x"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0076-8"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-020-06941-x"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs134"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01057.2004"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29044"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.5192"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.314681"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606203342507"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000136025.96811.76"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110487"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.156596"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0914"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.10.066"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16133"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.119.115725"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-019-09897-y"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.07.021"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-2835-0_6"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.607960"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7582730"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1029052"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2019.02.013"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1521020"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.08.023"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704495"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2919"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx060083i"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414665111"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074675"},{"key":"e_1_2_11_72_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: an update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat P. S.","year":"2021","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2800561"},{"key":"e_1_2_11_74_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568009621999210120192558"},{"key":"e_1_2_11_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02229"},{"key":"e_1_2_11_76_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20011672"},{"key":"e_1_2_11_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.12.009"},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz240"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319030"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4017"},{"key":"e_1_2_11_81_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051460"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.2.6"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1980763"},{"key":"e_1_2_11_84_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00475.2015"},{"key":"e_1_2_11_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(92)90050-A"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00617-06"},{"key":"e_1_2_11_87_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6093249"},{"key":"e_1_2_11_88_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1649"},{"key":"e_1_2_11_89_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102418"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/151972"},{"key":"e_1_2_11_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.05.003"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.12.008"},{"key":"e_1_2_11_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-009-0051-8"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.140301"},{"key":"e_1_2_11_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2006.63"},{"key":"e_1_2_11_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003917.pub4"},{"key":"e_1_2_11_98_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-842"},{"key":"e_1_2_11_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.692764"},{"key":"e_1_2_11_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.08.008"},{"key":"e_1_2_11_101_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6093783"},{"key":"e_1_2_11_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3308"},{"key":"e_1_2_11_103_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160385"},{"key":"e_1_2_11_104_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00113"},{"key":"e_1_2_11_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.06.003"},{"key":"e_1_2_11_106_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802663R"},{"key":"e_1_2_11_107_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2014"},{"key":"e_1_2_11_108_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-19-707"},{"key":"e_1_2_11_109_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010189"},{"key":"e_1_2_11_110_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035153"},{"key":"e_1_2_11_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101394"},{"key":"e_1_2_11_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110628"},{"key":"e_1_2_11_113_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570161053586903"},{"key":"e_1_2_11_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2012.03.006"},{"key":"e_1_2_11_115_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2019.0180"},{"key":"e_1_2_11_116_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020282"},{"key":"e_1_2_11_117_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3413-7"},{"key":"e_1_2_11_118_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.773834"},{"key":"e_1_2_11_119_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.813370"},{"key":"e_1_2_11_120_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1579"},{"key":"e_1_2_11_121_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8020"},{"key":"e_1_2_11_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111531"},{"key":"e_1_2_11_123_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11070910"},{"key":"e_1_2_11_124_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01595-x"},{"key":"e_1_2_11_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.050"},{"key":"e_1_2_11_126_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-030620-104842"},{"key":"e_1_2_11_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05005-9"},{"key":"e_1_2_11_128_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2616024"},{"key":"e_1_2_11_129_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1602816"},{"key":"e_1_2_11_130_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26071946"},{"key":"e_1_2_11_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112690"},{"key":"e_1_2_11_132_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1704119"},{"key":"e_1_2_11_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.114967"},{"key":"e_1_2_11_134_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4763"},{"key":"e_1_2_11_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22030"},{"key":"e_1_2_11_136_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-3195-6"},{"key":"e_1_2_11_137_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1586246"},{"key":"e_1_2_11_138_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-020-10056-x"},{"key":"e_1_2_11_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104846"},{"key":"e_1_2_11_140_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14466"},{"key":"e_1_2_11_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102185"},{"key":"e_1_2_11_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109547"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7176282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7176282.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7176282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:55:02Z","timestamp":1748915702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/7176282"}},"subtitle":[],"editor":[{"given":"Amadou","family":"Camara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":142,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/7176282"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7176282","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7176282"}}