{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:04:59Z","timestamp":1767168299066,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Projects in Scientific Research Foundation of National Health Commission and Medical Science and Technology Program of Zhejiang Province","award":["(WKJ-ZJ-1930)"],"award-info":[{"award-number":["(WKJ-ZJ-1930)"]}]},{"name":"Key Projects in Scientific Research Foundation of National Health Commission and Medical Science and Technology Program of Zhejiang Province","award":["(ZY2020010)"],"award-info":[{"award-number":["(ZY2020010)"]}]},{"name":"Key Projects in Scientific Research Foundation of National Health Commission and Medical Science and Technology Program of Zhejiang Province","award":["(82070933)"],"award-info":[{"award-number":["(82070933)"]}]},{"name":"Wenzhou Science and Technology Project; Social Development in Medicine and Health","award":["(WKJ-ZJ-1930)"],"award-info":[{"award-number":["(WKJ-ZJ-1930)"]}]},{"name":"Wenzhou Science and Technology Project; Social Development in Medicine and Health","award":["(ZY2020010)"],"award-info":[{"award-number":["(ZY2020010)"]}]},{"name":"Wenzhou Science and Technology Project; Social Development in Medicine and Health","award":["(82070933)"],"award-info":[{"award-number":["(82070933)"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(WKJ-ZJ-1930)"],"award-info":[{"award-number":["(WKJ-ZJ-1930)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(ZY2020010)"],"award-info":[{"award-number":["(ZY2020010)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["(82070933)"],"award-info":[{"award-number":["(82070933)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,3,18]]},"abstract":"<jats:p>Purpose. This study aimed to evaluate the medium-term fit of soft contact lenses (SCLs) and its effects on dry eye by using ultra-high-resolution optical coherence tomography (UHR-OCT) and digital slit-lamp biomicroscopy (DSLB) and identify factors indicating a better contact lens fit. Methods. A total of 14 participants (7 men, 7 women; mean age, 23.1 years) were recruited. Temporal lag and conjunctival coverage were imaged by UHR-OCT. DSLB was used to assess lens decentration and blink-induced movement. In addition, dry eye indices, including ocular surface disease index (OSDI), tear break-up time (TBUT), and Schirmer I test scores, were measured at baseline and 1 day, 1 week, 1 month, 3 months, and 6 months after wearing. Results. Good repeatability was found in the assessments of lens fit characteristics by two researchers and in the assessments by one researcher at different follow-up times. There were no significant differences in lens fit characteristics, TBUT and Schirmer I test scores at each checkpoint (P\u2009&gt;0.05). However, the OSDI was significantly higher than baseline after wearing (P\u2009&lt;0.05). Changes in the temporal lag were positively correlated with changes in TBUT (r\u2009=0.544, P\u2009=0.044) and negatively correlated with changes in OSDI (r\u2009=\u2009-0.629, P\u2009=0.016). Changes in blink-induced movement were positively correlated with changes in OSDI, Schirmer I test scores, and TBUT (P\u2009&lt;0.05). Conclusions. UHR-OCT and DSLB can be used to comprehensively and quantitatively evaluate SCL fit. Both the contact lenses and ocular surface conditions are almost stable within 6 months of SCL wear. Temporal lag and blink-induced movement have a strong correlation with dry eye parameters in SCL wearers.<\/jats:p>","DOI":"10.1155\/2022\/7220706","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T22:50:10Z","timestamp":1647643810000},"page":"1-14","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Medium-Term Soft Contact Lens Fitting on Dry Eye: Analyses Using Ultra-High Resolution Optical Coherence Tomography and Digital Slit-Lamp Biomicroscopy"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-954X","authenticated-orcid":true,"given":"Yuzhou","family":"Wang","sequence":"first","affiliation":[{"name":"School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-5006","authenticated-orcid":true,"given":"Zhiqiang","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-8037","authenticated-orcid":true,"given":"Shuangjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5066-6420","authenticated-orcid":true,"given":"Linzhi","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-6944","authenticated-orcid":true,"given":"Fan","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"},{"name":"National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, 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