{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:38:15Z","timestamp":1789767495950,"version":"4.0.1"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Vascular dementia (VaD) is the second most prevalent type of dementia characterized by progressive cognitive deficits and is a major risk factor for the development of Alzheimer\u2019s disease and other neurodegenerative disorders. This study is aimed at determining the potential neuroprotective effect of sitagliptin (STG) on cognitive deficits in L\u2010methionine\u2010induced VaD in rats and the possible underlying mechanisms. 30 adult male Wistar albino rats were divided equally (<jats:italic>n<\/jats:italic> = 10) into three groups: control, VaD, and VaD + STG groups. The cognitive performance of the animals was conducted by open field, elevated plus maze, Y\u2010maze, novel object recognition, and Morris water maze tests. Serum homocysteine, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20106, IL\u201010, total cholesterol, and triglycerides levels were assessed together with hippocampal MDA, SOD, and BDNF. Histopathological and immunohistochemical assessments of the thoracic aorta and hippocampus (CA1 region) were also performed. Chronic L\u2010methionine administration impaired memory and learning and induced anxiety. On the other hand, STG protected against cognitive deficits through improving oxidative stress biomarkers, inflammatory mediators, lipid profiles, and hippocampus level of BDNF as well as decreasing caspase\u20103 and GFAP and increasing Ki\u201067 immunoreactions in the hippocampus. Also, STG improved the endothelial dysfunction via upregulation of aortic eNOS immunoreaction. STG improved the cognitive deficits of L\u2010methionine\u2010induced VaD by its antioxidant, anti\u2010inflammatory, antiapoptotic, and neurotrophic effects. These findings suggest that STG may be a promising future agent for protection against VaD.<\/jats:p>","DOI":"10.1155\/2022\/7222590","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T15:50:09Z","timestamp":1645977009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sitagliptin Attenuates the Cognitive Deficits in L\u2010Methionine\u2010Induced Vascular Dementia in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-9445","authenticated-orcid":false,"given":"Suzan A.","family":"Khodir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5067-3543","authenticated-orcid":false,"given":"Manar A.","family":"Faried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-8683","authenticated-orcid":false,"given":"Huda I.","family":"Abd-Elhafiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-2648","authenticated-orcid":false,"given":"Eman M.","family":"Sweed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0427"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S302355"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/pm.pm_438_19"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00350"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-016-0688-z"},{"key":"e_1_2_9_6_2","first-page":"7","article-title":"The methionine-homocysteine cycle and its effects on cognitive diseases","volume":"8","author":"Miller A. 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