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To research the molecular mechanism of compound Danshen tablets in the treatment of hepatic fibrosis through network pharmacology. Methods. Traditional Chinese medicine systems pharmacology (TCMSP) and online Mendelian inheritance in man (OMIM) databases were searched for compound Danshen tablets\u2019 active ingredients o and hepatic fibrosis-related genes. The network enrichment of the targets of \u201cherb-compound-target\u201d was visualized and analyzed using Cytoscape software. Then, the screened target genes were used to construct a protein-protein interaction network. The DAVID enrichment database (the database for annotation, visualization, and integrated discovery) was adopted for GO (Gene Ontology) enrichment and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment of vital nodes. Results. The results yielded 234 targets of compound Danshen tablets; ten important targets (TNF, IL-10, TGF-\u03b21, EGF, CXCL16, CCL21, SERPINB5, SERPINA1, SOD2, and PPIG) for reversing hepatic fibrosis; and four core targets (TNF, IL-10, TGF-1, and EGF). In addition, KEGG enrichment analysis showed that compound Danshen tablets mainly involved FoxO and MAPK signaling pathways, as the key signaling pathways in the treatment of hepatic fibrosis. Conclusion. TNF, IL-10, TGF-1, and EGF and FOXO and MAPK signaling pathways play a key role in the pathogenesis of hepatic fibrosis. Based on the results of this study, the mechanism of action of compound Danshen tablets in the treatment of hepatic fibrosis may be associated with the regulation of FoxO and MAPK signaling pathways and inhibition of TNF, IL-10, TGF-1, and EGF.<\/jats:p>","DOI":"10.1155\/2022\/7241719","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T19:20:16Z","timestamp":1652210416000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Exploration on Molecular Mechanism of Reversal Effect of Compound Danshen Tablets on Hepatic Fibrosis Based on Network Pharmacology"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-5090","authenticated-orcid":true,"given":"Minling","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyue","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meifeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-1943","authenticated-orcid":true,"given":"Xiaoling","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0324-8"},{"key":"2","article-title":"Kindly provide the reference requested in paragraph one and include it as reference number 2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000835"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13058"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.618262"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/972863"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112442"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-4964(14)60039-X"},{"issue":"2","key":"9","first-page":"106","article-title":"Curative effect of entecavir combined with ganshuang granules on hepatitis B cirrhosis and its influences on liver function","volume":"47","author":"X. 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