{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:07:48Z","timestamp":1786435668519,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":243,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101720"],"award-info":[{"award-number":["82101720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. This systematic review and meta\u2010analysis aim at elucidating the heterogeneity in beneficial effects of antioxidant supplementation in obese adults by exploring the differential effects of antioxidant supplementation on basic indicators of obesity, lipid metabolism, systemic antioxidant capacity, inflammatory biomarkers, and liver function. <jats:italic>Methods<\/jats:italic>. The inclusion criteria specified randomized controlled trials with antioxidant intervention for adults (mean\u2009body\u2009mass\u2009index\u2009(BMI) &gt; 30), from inception to Aug. 8, 2021, in the PubMed, Embase, The Cochrane Library, Web of Science, and Scopus databases. Meta\u2010analysis and publication bias were performed using RevMan 5.4 software. Stata16 software was used to detect publication bias with Egger\u2019s and Begg\u2019s methods being mainly used. The data of basic indicators of obesity, lipid metabolism index, oxidative stress index, inflammatory biomarkers, and liver function index were collected to analyze the beneficial effects of antioxidant supplementation in obese patients. <jats:italic>Results<\/jats:italic>. A total of 30 studies were included in this study with a sample of 845 obese patients from the antioxidant supplementation group and 766 obese patients from the placebo control group. The meta\u2010analysis showed that obese patients with antioxidant supplementation had lower BMI (mean\u2009difference\u2009(MD):  \u2212 0.44 [95<jats:italic>%<\/jats:italic>confidence\u2009interval\u2009(CI):  \u2212 0.84, \u22120.04], <jats:italic>p<\/jats:italic> = 0.03), waist circumference (MD : \u22120.78\u2009[95<jats:italic>%<\/jats:italic>CI:\u22121.45, \u22120.11], <jats:italic>p<\/jats:italic> = 0.02), fasting blood glucose (FBG) level (standardized\u2009mean\u2009difference\u2009(SMD):  \u2212 4.92\u2009[95<jats:italic>%<\/jats:italic>CI:\u22126.87, \u22122.98], <jats:italic>p<\/jats:italic> &lt; 0.001) and homeostasis model assessment of insulin resistance (MD : \u22120.45\u2009[95<jats:italic>%<\/jats:italic>CI:\u22120.61, \u22120.3], <jats:italic>p<\/jats:italic> &lt; 0.001) when compared to the placebo group. Obese patients on antioxidant supplementation had lower levels of total cholesterol (SMD : \u22120.43\u2009[95<jats:italic>%<\/jats:italic>CI:\u22120.84, \u22120.02], <jats:italic>p<\/jats:italic> = 0.04), triglycerides (SMD : \u22120.17\u2009[95<jats:italic>%<\/jats:italic>CI:\u22120.31, \u22120.04], <jats:italic>p<\/jats:italic> = 0.01), low\u2010density lipoprotein (SMD : \u22120.15\u2009[95<jats:italic>%<\/jats:italic>CI:\u22120.29, \u22120.01], <jats:italic>p<\/jats:italic> = 0.03), malondialdehyde (SMD : \u22121.67\u2009[95<jats:italic>%<\/jats:italic>CI:\u22122.69, \u22120.65], <jats:italic>p<\/jats:italic> = 0.001), and tumor necrosis factor\u2010alpha (SMD : \u22120.29\u2009[95<jats:italic>%<\/jats:italic>CI:\u22120.56, \u22120.02], <jats:italic>p<\/jats:italic> = 0.03), respectively, when compared to the placebo group. In addition, obese patients with antioxidant supplementation had higher levels of high\u2010density lipoprotein (SMD : 0.25\u2009[95<jats:italic>%<\/jats:italic>CI : 0.03, 0.46], <jats:italic>p<\/jats:italic> = 0.03) and superoxide dismutase (SMD : 1.09\u2009[95<jats:italic>%<\/jats:italic>CI : 0.52, 1.65], <jats:italic>p<\/jats:italic> &lt; 0.001) when compared to the placebo group. Antioxidant supplementation had no effects on other analyzed parameters including waist\u2013hip ratio, leptin, fat mass, interleukin\u20106, C\u2010reactive protein, alanine transaminase, and aspartate transaminase in obese patients. <jats:italic>Conclusion<\/jats:italic>. The meta\u2010analysis results indicated that antioxidant supplementation exerted potential beneficial effects in obese patients by regulating FBG, oxidative stress, and inflammation, whilst more high\u2010quality studies are required to confirm these effects. The present study may provide important insights for the treatment of clinical obesity and obesity\u2010associated complications.<\/jats:p>","DOI":"10.1155\/2022\/7255413","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T19:50:08Z","timestamp":1662061808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta\u2010Analysis and Systematic Review"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jinyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ou","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-5082","authenticated-orcid":false,"given":"Xiaocan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-7151","authenticated-orcid":false,"given":"Yuli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy055"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614362"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.5455\/jcmr.2020.11.03.06"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.15586\/jptcp.v27iSP1.708"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12787"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1586\/erc.12.74"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i28.9330"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12053117"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0021-75572007000700011"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010023"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.07.018"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26020453"},{"key":"e_1_2_11_13_2","first-page":"2473","article-title":"Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study","volume":"21","author":"Szulinska M.","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12784"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02261A"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1459497"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007807.pub3"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.02.002"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.17179\/excli2016-846"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-12-42"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007807.pub4"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007411.pub4"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316101"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.13617"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062121"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.222414"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000184"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.12.007"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-018-0426-y"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1529654"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082512"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S83144"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.005"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.10.4.497"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu5041218"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15551"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6402"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2012.05.007"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/2008-2231-20-33"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0778"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.12.022"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2016.04.011"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.0039"},{"key":"e_1_2_11_45_2","first-page":"634","article-title":"Inflammatory\/haematopoietic cytokine production by human bone marrow adipocytes","volume":"11","author":"Laharrague P.","year":"2000","journal-title":"European Cytokine Network"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0583"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.07.005"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2013.09.010"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109199"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.154015"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8040096"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.183"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7255413.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7255413.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7255413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:14:16Z","timestamp":1748909656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/7255413"}},"subtitle":[],"editor":[{"given":"Sonia","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/7255413"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7255413","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7255413"}}