{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:16:53Z","timestamp":1789474613934,"version":"build-2803163510"},"reference-count":328,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":128,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016966","name":"Bethune Charitable Foundation","doi-asserted-by":"publisher","award":["B-19-H-20200622"],"award-info":[{"award-number":["B-19-H-20200622"]}],"id":[{"id":"10.13039\/100016966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Chemotherapy\u2010induced intestinal mucositis (CIM) is a significant dose\u2010limiting adverse reaction brought on by the cancer treatment. Multiple studies reported that reactive oxygen species (ROS) is rapidly produced during the initial stages of chemotherapy, when the drugs elicit direct damage to intestinal mucosal cells, which, in turn, results in necrosis, mitochondrial dysfunction, and ROS production. However, the mechanism behind the intestinal redox system\u2010based induction of intestinal mucosal injury and necrosis of CIM is still undetermined. In this article, we summarized relevant information regarding the intestinal redox system, including the composition and regulation of redox enzymes, ROS generation, and its regulation in the intestine. We innovatively proposed the intestinal redox \u201cTai Chi\u201d theory and revealed its significance in the pathogenesis of CIM. We also conducted an extensive review of the English language\u2010based literatures involving oxidative stress (OS) and its involvement in the pathological mechanisms of CIM. From the date of inception till July 31, 2021, 51 related articles were selected. Based on our analysis of these articles, only five chemotherapeutic drugs, namely, MTX, 5\u2010FU, cisplatin, CPT\u201011, and oxaliplatin were shown to trigger the ROS\u2010based pathological mechanisms of CIM. We also discussed the redox system\u2010mediated modulation of CIM pathogenesis via elaboration of the relationship between chemotherapeutic drugs and the redox system. It is our belief that this overview of the intestinal redox system and its role in CIM pathogenesis will greatly enhance research direction and improve CIM management in the future.<\/jats:p>","DOI":"10.1155\/2022\/7255497","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T21:35:09Z","timestamp":1652132109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Intestinal Redox System and Its Significance in Chemotherapy\u2010Induced Intestinal Mucositis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-6747","authenticated-orcid":false,"given":"Qing-Qing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1946-1996","authenticated-orcid":false,"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-8595","authenticated-orcid":false,"given":"Yujin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-5092","authenticated-orcid":false,"given":"Baoqin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8360-7427","authenticated-orcid":false,"given":"Pei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"e_1_2_17_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28592"},{"key":"e_1_2_17_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv202"},{"key":"e_1_2_17_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00354"},{"key":"e_1_2_17_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1318"},{"key":"e_1_2_17_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1810-y"},{"key":"e_1_2_17_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-015-0474-9"},{"key":"e_1_2_17_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00060-9"},{"key":"e_1_2_17_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5450.138"},{"key":"e_1_2_17_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00258-4"},{"key":"e_1_2_17_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/43459"},{"key":"e_1_2_17_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32975"},{"key":"e_1_2_17_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1824"},{"key":"e_1_2_17_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.299"},{"key":"e_1_2_17_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00198.2004"},{"key":"e_1_2_17_15_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1104fje"},{"key":"e_1_2_17_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3671"},{"key":"e_1_2_17_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406486200"},{"key":"e_1_2_17_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509255200"},{"key":"e_1_2_17_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.04.004"},{"key":"e_1_2_17_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00135.2005"},{"key":"e_1_2_17_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.08.022"},{"key":"e_1_2_17_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5444"},{"key":"e_1_2_17_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220981"},{"key":"e_1_2_17_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405406200"},{"key":"e_1_2_17_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212856200"},{"key":"e_1_2_17_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)36882-6"},{"key":"e_1_2_17_27_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2960557"},{"key":"e_1_2_17_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301289200"},{"key":"e_1_2_17_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.6.2160-2174.2006"},{"key":"e_1_2_17_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512751200"},{"key":"e_1_2_17_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.210"},{"key":"e_1_2_17_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513665200"},{"key":"e_1_2_17_33_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.1.6"},{"key":"e_1_2_17_34_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1260747"},{"key":"e_1_2_17_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(00)00203-9"},{"key":"e_1_2_17_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.05.022"},{"key":"e_1_2_17_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00956-5"},{"key":"e_1_2_17_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06489.x"},{"key":"e_1_2_17_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvm053"},{"key":"e_1_2_17_40_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0262"},{"key":"e_1_2_17_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1996.270.6.L941"},{"key":"e_1_2_17_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00561.2002"},{"key":"e_1_2_17_43_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0367"},{"key":"e_1_2_17_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.11.008"},{"key":"e_1_2_17_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91060-U"},{"key":"e_1_2_17_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1994.267.2.G270"},{"key":"e_1_2_17_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2012.02.004"},{"key":"e_1_2_17_48_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3570593"},{"key":"e_1_2_17_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000661e"},{"key":"e_1_2_17_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406204200"},{"key":"e_1_2_17_51_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01166"},{"key":"e_1_2_17_52_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4744"},{"key":"e_1_2_17_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.07.010"},{"key":"e_1_2_17_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.5.984"},{"key":"e_1_2_17_55_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00627.x"},{"key":"e_1_2_17_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/21224"},{"key":"e_1_2_17_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/21218"},{"key":"e_1_2_17_58_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.9.6123"},{"key":"e_1_2_17_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003198200"},{"key":"e_1_2_17_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.29.20597"},{"key":"e_1_2_17_61_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2012.667566"},{"key":"e_1_2_17_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.03.004"},{"key":"e_1_2_17_63_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0704396"},{"key":"e_1_2_17_64_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1999.60.07.807"},{"key":"e_1_2_17_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.03.012"},{"key":"e_1_2_17_66_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115607946"},{"key":"e_1_2_17_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.02.001"},{"key":"e_1_2_17_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2005.08.009"},{"key":"e_1_2_17_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1997.tb00940.x"},{"key":"e_1_2_17_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020403"},{"key":"e_1_2_17_71_2","first-page":"848","article-title":"Identification and characterization of the human myeloperoxidase promoter","volume":"9","author":"Austin G. E.","year":"1995","journal-title":"Leukemia"},{"key":"e_1_2_17_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(96)00032-X"},{"key":"e_1_2_17_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402514"},{"key":"e_1_2_17_74_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.2.345.345"},{"key":"e_1_2_17_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90362-Z"},{"key":"e_1_2_17_76_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00416a013"},{"key":"e_1_2_17_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.4.2141-2151.1993"},{"key":"e_1_2_17_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.8.5558"},{"key":"e_1_2_17_79_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.24.14412"},{"key":"e_1_2_17_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.18.8229"},{"key":"e_1_2_17_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4343"},{"key":"e_1_2_17_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01004718"},{"key":"e_1_2_17_83_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3458"},{"key":"e_1_2_17_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.017"},{"key":"e_1_2_17_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.10.814"},{"key":"e_1_2_17_86_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3280599"},{"key":"e_1_2_17_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a130592"},{"key":"e_1_2_17_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.102"},{"key":"e_1_2_17_89_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.48.34277"},{"key":"e_1_2_17_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700612"},{"key":"e_1_2_17_91_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503991200"},{"key":"e_1_2_17_92_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0740339"},{"key":"e_1_2_17_93_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0310509"},{"key":"e_1_2_17_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.10.048"},{"key":"e_1_2_17_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00275-2"},{"key":"e_1_2_17_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1202"},{"key":"e_1_2_17_97_2","first-page":"363","article-title":"Intracellular localization of the copper-zinc and manganese superoxide dismutases in rat liver parenchymal cells","volume":"55","author":"Slot J. W.","year":"1986","journal-title":"Laboratory Investigation"},{"key":"e_1_2_17_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00328-0"},{"key":"e_1_2_17_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36254-3"},{"key":"e_1_2_17_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90270-M"},{"key":"e_1_2_17_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(91)90569-R"},{"key":"e_1_2_17_102_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi951892w"},{"key":"e_1_2_17_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2009.11.005"},{"key":"e_1_2_17_104_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00011a003"},{"key":"e_1_2_17_105_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp052368u"},{"key":"e_1_2_17_106_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0266481"},{"key":"e_1_2_17_107_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi9929958"},{"key":"e_1_2_17_108_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi7014103"},{"key":"e_1_2_17_109_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.847"},{"key":"e_1_2_17_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41283-2_17"},{"key":"e_1_2_17_111_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2055"},{"key":"e_1_2_17_112_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2057"},{"key":"e_1_2_17_113_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4073.588"},{"key":"e_1_2_17_114_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033066"},{"key":"e_1_2_17_115_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05774.x"},{"key":"e_1_2_17_116_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00107a003"},{"key":"e_1_2_17_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(82)90150-3"},{"key":"e_1_2_17_118_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1994.266.2.C367"},{"key":"e_1_2_17_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.23.7144"},{"key":"e_1_2_17_120_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3330005"},{"key":"e_1_2_17_121_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407141200"},{"key":"e_1_2_17_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.09.085"},{"key":"e_1_2_17_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.09.074"},{"key":"e_1_2_17_124_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21506"},{"key":"e_1_2_17_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.12.005"},{"key":"e_1_2_17_126_2","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2016-000361"},{"key":"e_1_2_17_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2010.05.004"},{"key":"e_1_2_17_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.11.021"},{"key":"e_1_2_17_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53812-6"},{"key":"e_1_2_17_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(98)00032-4"},{"key":"e_1_2_17_131_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0115"},{"key":"e_1_2_17_132_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00014.2001"},{"key":"e_1_2_17_133_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00064.2011"},{"key":"e_1_2_17_134_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5432.1393"},{"key":"e_1_2_17_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(90)90128-K"},{"key":"e_1_2_17_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.02.017"},{"key":"e_1_2_17_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.12.039"},{"key":"e_1_2_17_138_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/180906"},{"key":"e_1_2_17_139_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.9962"},{"key":"e_1_2_17_140_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760100301181"},{"key":"e_1_2_17_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.08.029"},{"key":"e_1_2_17_142_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00662.2009"},{"key":"e_1_2_17_143_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00012.x"},{"key":"e_1_2_17_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04350.x"},{"key":"e_1_2_17_145_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050004"},{"key":"e_1_2_17_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82146-9"},{"key":"e_1_2_17_147_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2003.002"},{"key":"e_1_2_17_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.11.020"},{"key":"e_1_2_17_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.06.026"},{"key":"e_1_2_17_150_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.5.1013"},{"key":"e_1_2_17_151_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12321"},{"key":"e_1_2_17_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101343"},{"key":"e_1_2_17_153_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152549"},{"key":"e_1_2_17_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.05.047"},{"key":"e_1_2_17_155_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3809-3"},{"key":"e_1_2_17_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.07.018"},{"key":"e_1_2_17_157_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3070377"},{"key":"e_1_2_17_158_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.49.30952"},{"key":"e_1_2_17_159_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.11.6303"},{"key":"e_1_2_17_160_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.11.6297"},{"key":"e_1_2_17_161_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R111.283432"},{"key":"e_1_2_17_162_2","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2002.040"},{"key":"e_1_2_17_163_2","doi-asserted-by":"publisher","DOI":"10.1080\/15216540252774748"},{"key":"e_1_2_17_164_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110432200"},{"key":"e_1_2_17_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(02)00003-8"},{"key":"e_1_2_17_166_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3540209"},{"key":"e_1_2_17_167_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022451"},{"key":"e_1_2_17_168_2","doi-asserted-by":"publisher","DOI":"10.1515\/bchm.1997.378.8.827"},{"key":"e_1_2_17_169_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2700"},{"key":"e_1_2_17_170_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.28937"},{"key":"e_1_2_17_171_2","doi-asserted-by":"publisher","DOI":"10.1177\/15353702-0322805-02"},{"key":"e_1_2_17_172_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000075568.93053.fa"},{"key":"e_1_2_17_173_2","first-page":"57","article-title":"CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE\/2E1","volume":"11","author":"Takahashi S.","year":"2003","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_17_174_2","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0b013e3180cab913"},{"key":"e_1_2_17_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90460-8"},{"key":"e_1_2_17_176_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02950-8"},{"key":"e_1_2_17_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00127-5"},{"key":"e_1_2_17_178_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10393"},{"key":"e_1_2_17_179_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.278.4.L806"},{"key":"e_1_2_17_180_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/13.2.227"},{"key":"e_1_2_17_181_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5364"},{"key":"e_1_2_17_182_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.275.3.L583"},{"key":"e_1_2_17_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)39059-3"},{"key":"e_1_2_17_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48315-9"},{"key":"e_1_2_17_185_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb13811.x"},{"key":"e_1_2_17_186_2","doi-asserted-by":"publisher","DOI":"10.1038\/12319"},{"key":"e_1_2_17_187_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00214a012"},{"key":"e_1_2_17_188_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42212-5"},{"key":"e_1_2_17_189_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.517"},{"key":"e_1_2_17_190_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.15.1.8679227"},{"key":"e_1_2_17_191_2","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2017.00078"},{"key":"e_1_2_17_192_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.09.005"},{"key":"e_1_2_17_193_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135844"},{"key":"e_1_2_17_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00307-1"},{"key":"e_1_2_17_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00061-1"},{"key":"e_1_2_17_196_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.181628"},{"key":"e_1_2_17_197_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"e_1_2_17_198_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.002"},{"key":"e_1_2_17_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.10.016"},{"key":"e_1_2_17_200_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045037"},{"key":"e_1_2_17_201_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"e_1_2_17_202_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117439"},{"key":"e_1_2_17_203_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/54.1.52"},{"key":"e_1_2_17_204_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.611509"},{"key":"e_1_2_17_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.03.014"},{"key":"e_1_2_17_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05640-8"},{"key":"e_1_2_17_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.11.016"},{"key":"e_1_2_17_208_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021775524062"},{"key":"e_1_2_17_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.01.011"},{"key":"e_1_2_17_210_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01266.x"},{"key":"e_1_2_17_211_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.11.2739"},{"key":"e_1_2_17_212_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132208"},{"key":"e_1_2_17_213_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.116764"},{"key":"e_1_2_17_214_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04690.x"},{"key":"e_1_2_17_215_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132418"},{"key":"e_1_2_17_216_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1984.247.4.G394"},{"key":"e_1_2_17_217_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.4.1016"},{"key":"e_1_2_17_218_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470123096.ch2"},{"key":"e_1_2_17_219_2","first-page":"G292","article-title":"Secretion of cysteine and glutathione from mucosa to lumen in rat small intestine","volume":"267","author":"Dahm L. J.","year":"1994","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_17_220_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783999"},{"key":"e_1_2_17_221_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(70)90980-0"},{"key":"e_1_2_17_222_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0710118"},{"key":"e_1_2_17_223_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00359.2009"},{"key":"e_1_2_17_224_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311401"},{"key":"e_1_2_17_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.035"},{"key":"e_1_2_17_226_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-405881-1.00001-X"},{"key":"e_1_2_17_227_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.09.010"},{"key":"e_1_2_17_228_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1695"},{"key":"e_1_2_17_229_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.10.009"},{"key":"e_1_2_17_230_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.05.020"},{"key":"e_1_2_17_231_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.3.527"},{"key":"e_1_2_17_232_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.544635"},{"key":"e_1_2_17_233_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(73)90040-4"},{"key":"e_1_2_17_234_2","article-title":"Antioxidant-prooxidant balance in the intestine: applications in chick placement and pig weaning","volume":"3","author":"Surai P.","year":"2015","journal-title":"Journal of Veterinary Science & Medicine"},{"key":"e_1_2_17_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.12.048"},{"key":"e_1_2_17_236_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"e_1_2_17_237_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130404-200609000-00004"},{"key":"e_1_2_17_238_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12019"},{"key":"e_1_2_17_239_2","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2017.1402976"},{"key":"e_1_2_17_240_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36878-z"},{"key":"e_1_2_17_241_2","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2016-0043"},{"key":"e_1_2_17_242_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01886J"},{"key":"e_1_2_17_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.09.035"},{"key":"e_1_2_17_244_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106018"},{"key":"e_1_2_17_245_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01036"},{"key":"e_1_2_17_246_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0295-8"},{"key":"e_1_2_17_247_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116888"},{"key":"e_1_2_17_248_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.2849"},{"key":"e_1_2_17_249_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.1.76"},{"key":"e_1_2_17_250_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080699"},{"key":"e_1_2_17_251_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2803"},{"key":"e_1_2_17_252_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141046"},{"key":"e_1_2_17_253_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0516"},{"key":"e_1_2_17_254_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp176"},{"key":"e_1_2_17_255_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-0811"},{"key":"e_1_2_17_256_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.10.017"},{"key":"e_1_2_17_257_2","doi-asserted-by":"publisher","DOI":"10.1080\/10495398.2019.1610416"},{"key":"e_1_2_17_258_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.10.013"},{"key":"e_1_2_17_259_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2014.55.5.1196"},{"key":"e_1_2_17_260_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01064"},{"key":"e_1_2_17_261_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.6.486"},{"key":"e_1_2_17_262_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.11.1272"},{"key":"e_1_2_17_263_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-019-03854-x"},{"key":"e_1_2_17_264_2","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v9i3.17"},{"key":"e_1_2_17_265_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072553"},{"key":"e_1_2_17_266_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.03.032"},{"key":"e_1_2_17_267_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327113515503"},{"key":"e_1_2_17_268_2","doi-asserted-by":"publisher","DOI":"10.1159\/000442020"},{"key":"e_1_2_17_269_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.19-0057"},{"key":"e_1_2_17_270_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.02.035"},{"key":"e_1_2_17_271_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.4.1789"},{"key":"e_1_2_17_272_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520902605"},{"key":"e_1_2_17_273_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-013-2115-z"},{"key":"e_1_2_17_274_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311625200"},{"key":"e_1_2_17_275_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27989"},{"key":"e_1_2_17_276_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-010-9141-9"},{"key":"e_1_2_17_277_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-011-9201-y"},{"key":"e_1_2_17_278_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30625-8"},{"key":"e_1_2_17_279_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.12.037"},{"key":"e_1_2_17_280_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.10.001"},{"key":"e_1_2_17_281_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.257"},{"key":"e_1_2_17_282_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.03.009"},{"key":"e_1_2_17_283_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2798-8"},{"key":"e_1_2_17_284_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2004.05.002"},{"key":"e_1_2_17_285_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.095"},{"key":"e_1_2_17_286_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.006"},{"key":"e_1_2_17_287_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.04.011"},{"key":"e_1_2_17_288_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02047.x"},{"key":"e_1_2_17_289_2","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2020.44948.10482"},{"key":"e_1_2_17_290_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102341200"},{"key":"e_1_2_17_291_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027387301845"},{"key":"e_1_2_17_292_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00480-0"},{"key":"e_1_2_17_293_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.99-0799com"},{"key":"e_1_2_17_294_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7591840"},{"key":"e_1_2_17_295_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i10.1503"},{"key":"e_1_2_17_296_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04891-1"},{"key":"e_1_2_17_297_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.03.012"},{"key":"e_1_2_17_298_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410003605"},{"key":"e_1_2_17_299_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-35"},{"key":"e_1_2_17_300_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6311"},{"key":"e_1_2_17_301_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25122786"},{"key":"e_1_2_17_302_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114567508"},{"key":"e_1_2_17_303_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph12020051"},{"key":"e_1_2_17_304_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.09.012"},{"key":"e_1_2_17_305_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.1004730"},{"key":"e_1_2_17_306_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115573597"},{"key":"e_1_2_17_307_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph13010010"},{"key":"e_1_2_17_308_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-019-03865-8"},{"key":"e_1_2_17_309_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8893"},{"key":"e_1_2_17_310_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2437-4"},{"key":"e_1_2_17_311_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.03.004"},{"key":"e_1_2_17_312_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14987"},{"key":"e_1_2_17_313_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.01.051"},{"key":"e_1_2_17_314_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.12.014"},{"key":"e_1_2_17_315_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.06.006"},{"key":"e_1_2_17_316_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1759659"},{"key":"e_1_2_17_317_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.07.006"},{"key":"e_1_2_17_318_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.17.9203"},{"key":"e_1_2_17_319_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR07981B"},{"key":"e_1_2_17_320_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758835918821021"},{"key":"e_1_2_17_321_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.03.056"},{"key":"e_1_2_17_322_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1119-1"},{"key":"e_1_2_17_323_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01795-2"},{"key":"e_1_2_17_324_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15162"},{"key":"e_1_2_17_325_2","doi-asserted-by":"publisher","DOI":"10.3920\/BM2015.0190"},{"key":"e_1_2_17_326_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8060876"},{"key":"e_1_2_17_327_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.09.007"},{"key":"e_1_2_17_328_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513004248"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7255497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7255497.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7255497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:01:30Z","timestamp":1748908890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/7255497"}},"subtitle":[],"editor":[{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":328,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/7255497"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7255497","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7255497"}}