{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:21:37Z","timestamp":1753881697057,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2018BHF2001"],"award-info":[{"award-number":["2018BHF2001"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560684","81860753"],"award-info":[{"award-number":["81560684","81860753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2019AAC03084"],"award-info":[{"award-number":["2019AAC03084"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>As a traditional Chinese medicine formula, Mi\u2010Jian\u2010Chang\u2010Pu decoction (MJCPD) has been successfully used in patients with language dysfunction and hemiplegia after ischemic stroke (IS). Given the excellent protective effects of MJCPD against nerve damage caused by IS in clinical settings, the present investigation mainly focused on its underlying mechanism on ischemia\u2010reperfusion (IR) injury. Firstly, by applying the MCAO\u2010induced cerebral IR injury rats, the efficacy of MJCPD on IS was estimated using the neurological deficit score, TTC, HE, and IHC staining, and neurochemical measurements. Secondly, an UHPLC\u2010QTOF\u2010MS\/MS\u2010based nontargeted metabolomics was developed to elucidate the characteristic metabolites. MJCPD groups showed significant improvements in the neurological score, infarction volume, and histomorphology, and the changes of GSH, GSSG, GSH\u2010PX, GSSG\/GSH, LDH, L\u2010LA, IL\u20106, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and VEGF\u2010c were also reversed to normal levels after the intervention compared to the MCAO model group. Metabolomics profiling identified 21 different metabolites in the model group <jats:italic>vs.<\/jats:italic> the sham group, 10 of which were significantly recovered after treatment of MJCPD, and those 10 metabolites were all related to the oxidative stress process including glucose, fatty acid, amino acid, glutamine, and phospholipid metabolisms. Therefore, MJCPD might protect against IS by inhibiting oxidative stress during IR.<\/jats:p>","DOI":"10.1155\/2022\/7319563","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T04:05:09Z","timestamp":1651896309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Potential Therapeutic Effects of Mi\u2010Jian\u2010Chang\u2010Pu Decoction on Neurochemical and Metabolic Changes of Cerebral Ischemia\u2010Reperfusion Injury in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-0619","authenticated-orcid":false,"given":"Jingjing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1149-3237","authenticated-orcid":false,"given":"Lingling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-1560","authenticated-orcid":false,"given":"Yang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3310-7819","authenticated-orcid":false,"given":"Chao","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-1673","authenticated-orcid":false,"given":"Yingli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-8368","authenticated-orcid":false,"given":"Ruru","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-6524","authenticated-orcid":false,"given":"Jianyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-5967","authenticated-orcid":false,"given":"Xueqin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1917030"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1667-0"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-007-8013-9"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S210035"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.04.051"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.531632"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9029-6"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.139"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2013.02.006"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.2.143"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.670885"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.04.031"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/2210315506666160819154213"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.02.018"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5374.2013.28.004"},{"key":"e_1_2_11_16_2","article-title":"Textual research on Huihui prescription","volume":"2","author":"Song X.","year":"2007","journal-title":"Zhonghua Book Company"},{"key":"e_1_2_11_17_2","unstructured":"GuY. Effects on Mjjian Changpu Prescription on Vascular Cognitive Impairment and Neurotrophic Factors in Patients with Cerebral Infraction of Intermingled Phlegm and Stasis Type [M.S.thesis] 2018."},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3566"},{"key":"e_1_2_11_19_2","first-page":"474","article-title":"Inhibitory effects of aqueous crude extract of saffron (Crocus sativus L.) on chemical-induced genotoxicity in mice","volume":"12","author":"Premkumar K.","year":"2003","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)01729-0"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.013"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.130.737"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.8.1037"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4258"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12645"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01729A"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.190555"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.931"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.01.030"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(17)30069-9"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3535"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00139-2"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.07.011"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400476"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306964"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-019-02829-x"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-201152"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.03.059"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2016.40.1.177"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1638-x"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.02.022"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13249"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600543"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1500"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.598789"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7319563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/7319563.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7319563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:54:05Z","timestamp":1748912045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/7319563"}},"subtitle":[],"editor":[{"given":"ChongDe","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/7319563"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7319563","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"type":"print","value":"1942-0900"},{"type":"electronic","value":"1942-0994"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7319563"}}