{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:45:11Z","timestamp":1792079111482,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":258,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . This study aimed to compare the intranasal administration of midazolam and dexmedetomidine in uncooperative children with Down syndrome.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . The sample consisted of 20 children with Down syndrome aged 5 to 11 years who were divided equally into two groups: Group 1 (experimental) nasal dexmedetomidine and Group 2 (control) nasal midazolam. The efficacy of both the drugs was evaluated according to Ohio State University Behavioral Rating Scale (OSUBRS), University of Michigan scale (UMSS), and Houpt general behavior scale.\n                    <jats:italic>Results<\/jats:italic>\n                    . Both substances have been effective in the management of children with Down syndrome. There were no statistically significant differences for Ohio State University Behavioral Rating Scale (OSUBRS) (\n                    <jats:italic>P<\/jats:italic>\n                    value\u2009=\u20090.631), University of Michigan scale (UMSS) (\n                    <jats:italic>P<\/jats:italic>\n                    value\u2009=\u20090.739), and Houpt general behavior scale (\n                    <jats:italic>P<\/jats:italic>\n                    value\u2009=\u20090.481).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Both midazolam and dexmedetomidine nasal can be used to sedate children with Down syndrome.\n                  <\/jats:p>","DOI":"10.1155\/2022\/7344928","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T16:05:24Z","timestamp":1663344324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the Efficacy of Nasal Sedation Midazolam Compared with Dexmedetomidine in the Management of Uncooperative Children with Down Syndrome during Dental Treatment"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5013-0976","authenticated-orcid":false,"given":"Mohamad Nabil","family":"Hamod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-7037","authenticated-orcid":false,"given":"Chaza","family":"Kouchaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4883-1001","authenticated-orcid":false,"given":"Faten","family":"Rostom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-7720","authenticated-orcid":false,"given":"Hasan","family":"Alzoubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-7694","authenticated-orcid":false,"given":"Imad","family":"Katbeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8048-5703","authenticated-orcid":false,"given":"Nikolay","family":"Tuturov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)12987-x"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-006-9057-8"},{"key":"e_1_2_8_3_2","article-title":"Facial reconstruction in down syndrome: perceptions of the results by parents and normal adolescents","volume":"26","author":"Klaiman P.","year":"1989","journal-title":"Cleft Palate Journal"},{"key":"e_1_2_8_4_2","unstructured":"American Academy on Pediatric Dentistry Ad Hoc Committee on Sedation and Anesthesia; American Academy on Pediatric Dentistry Council on Clinical Affairs. Policy on the use of deep sedation and general anesthesia in the pediatric dental office. Pediatric Dentistry Journal vol. 30 no. 7 Suppl 66\u201367 2008."},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-60826-8.00024-9"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12687"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00075198-200108000-00002"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s5374"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200008000-00016"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12287"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.38.3.l828585807482966"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-60826-8.00008-0"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/acm.0b013e31815c6247"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.2.241"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13120"},{"key":"e_1_2_8_16_2","first-page":"79","article-title":"Intranasal premedication effect of dexmedetomidine versus midazolam on the behavior of 2\u20136-year-old uncooperative children in dental clinic","volume":"15","author":"Mahdavi A.","year":"2018","journal-title":"Journal of Dentistry"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2012.03802.x"}],"container-title":["International Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7344928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/2022\/7344928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7344928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:59:23Z","timestamp":1792076363000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/7344928"}},"subtitle":[],"editor":[{"given":"Alessandro","family":"Leite Cavalcanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/7344928"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7344928","archive":["Portico"],"relation":{},"ISSN":["1687-8728","1687-8736"],"issn-type":[{"value":"1687-8728","type":"print"},{"value":"1687-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7344928"}}