{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:19:47Z","timestamp":1783397987223,"version":"3.54.6"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,4,30]]},"abstract":"<jats:p>Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) are the common herbs used for culinary purposes in daily life. The chlorophyll pigment in plants is being identified with various medicinal values, whereas iron is an essential micronutrient for the proper metabolism of the human body. The current research has been aimed at predicting the role of C. sativum and P. crispum in enhancing iron absorption via an in vitro approach. C. sativum and P. crispum have been analyzed for their capability of being a source of chlorophyll and iron concentration. The extracts prepared from solvents like carbinol, petroleum ether, and water were subjected to the identification of phytoconstituents through gas chromatography-mass spectrometry analysis, and the identified compounds were subjected to in silico studies against the iron-binding receptor, transferrin, to depict the binding affinity of the identified compounds. The carbinol extract was then put through in vitro analytical studies in Caco2 cell lines with a concentration of 500\u2009\u00b5g\/ml. Current research has shown that the leaves of C. sativum and P. crispum are an excellent source of chlorophyll and iron and has also suggested that these herbs efficiently enhance the absorption of iron in human intestinal cells.<\/jats:p>","DOI":"10.1155\/2022\/7359081","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T19:35:08Z","timestamp":1651347308000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in Enhancing Iron Absorption: An In Silico and In Vitro Approach"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5069-6304","authenticated-orcid":true,"given":"T.","family":"Sangeetha","sequence":"first","affiliation":[{"name":"Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5544-8281","authenticated-orcid":true,"given":"K. Syed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"PG & Research Department of Botany, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-4925","authenticated-orcid":true,"given":"S.","family":"Deepa","sequence":"additional","affiliation":[{"name":"PG & Research Department of Botany, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-1495","authenticated-orcid":true,"given":"B.","family":"Balamuralikrishnan","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Sejong University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-1907","authenticated-orcid":true,"given":"S.","family":"Velayuthaprabhu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bharathiar University, Tamil Nadu, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2639-3186","authenticated-orcid":true,"given":"K. M.","family":"Saradhadevi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Bharathiar University, Tamil Nadu, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-1586","authenticated-orcid":true,"given":"A. Vijaya","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2021-3668"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9715060"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27625"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s2095-4964(17)60317-0"},{"key":"5","first-page":"186","article-title":"Evaluation of neuroprotective effect of Coriandrum sativum Linn. against ischemicreperfusion insult in brain","volume":"2","author":"R. H. Vekaria","year":"2012","journal-title":"International Journal of Phytopharmacology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-020-02601-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076516"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020378"},{"key":"9","volume-title":"Biochemistry, Iron Absorption. [Updated 2021 Apr 26]. in: StatPearls [Internet].","author":"T. Ems","year":"2021"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.09.016"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1104\/pp.24.1.1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1021\/i560096a013"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3390\/md19020091"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05321"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.5455\/spatula.20110106123153"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.5897\/ajps2013.1118"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-015-2071-1"},{"key":"18","first-page":"55","article-title":"Growth, anatomy and chlorophyll fluorescence of coriander plants (Coriandrum sativum L.) treated with prohexadione-calcium and daminozide","volume":"50","author":"G. Kofidis","year":"2008","journal-title":"Acta Biologica Cracoviensia - Series Botanica"},{"issue":"212","key":"19","first-page":"02","article-title":"Microwave drying - a promising alternative for the herb processing industry","volume":"06","author":"K. Kathirvel","year":"2006","journal-title":"CSBE 2006 Annual Conference Proceedings"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s12298-012-0105-y"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2014.01.004"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.17306\/j.afs.2014.2.4"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3390\/plants10071391"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3390\/agronomy11050857"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.14233\/ajchem.2018.20930"},{"key":"26","first-page":"30","article-title":"Effect of spraying with zinc and\/or iron on growth and chemical composition of coriander (Coriandrum sativum L.) harvested at three stages of development","volume":"1","author":"H. A. H. Said-Al Ahl","year":"2009","journal-title":"Journal of Medicinal Food Plants"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115546"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217889"},{"issue":"08","key":"29","first-page":"069","article-title":"Carotene content of coriander leaves (Coriandrum sativum), amaranth, red (Amaranthus sp), green garlic (Allium sativum) and mogri (Raphanus caudatus) and its products","volume":"4","author":"S. N. Vanisha","year":"2014","journal-title":"Journal of Applied Pharmaceutical Science"},{"issue":"5","key":"30","first-page":"312","article-title":"Protective effect of Petroselinum crispum extract in abortion using prostadin-induced renal dysfunction in female rats","volume":"4","author":"M. Rezazad","year":"2014","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.5812\/jjnpp.65028"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26072009"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.3390\/toxics9060123"},{"key":"34","first-page":"55","article-title":"In silico analysis of Coriandrum Sativum against sPLA2 as a therapeutic target protein for Antiasthmatic activity","author":"S. Lakshmana Prabu","year":"2016","journal-title":"International Journal of Research in Pharmacology & Pharmacotherapeutics"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.3390\/ph14080770"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1329"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.02.001"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7359081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7359081.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7359081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T19:35:16Z","timestamp":1651347316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/7359081\/"}},"subtitle":[],"editor":[{"given":"Ruchika","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,30]]},"references-count":37,"alternative-id":["7359081","7359081"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7359081","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,30]]}}}