{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:37:13Z","timestamp":1775219833478,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,27]]},"abstract":"<jats:p>Background. Psoriasis is a chronic noncommunicable dermatological condition, and psoriasis vulgaris is the most common phenotype. Acitretin is the most widely used systemic retinoid in the treatment of psoriasis. This review evaluates the clinical therapeutic effects of Xiaoyin granule, a Chinese herbal medicine, combined with acitretin capsule in the treatment of psoriasis vulgaris. Methods. Six databases including PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Wan Fang, and China Biology Medicine disc (CBM) were searched for published studies on Xiaoyin granule and\/or acitretin capsule in psoriasis vulgaris. The Cochrane Collaboration risk-of-bias instrument was used to assess the quality of the included RCTs. STATA 14.0 was used to conduct the statistical analysis. Results. Twenty-eight trials with 3281 patients were included in this meta-analysis. The results of this study show that the combined treatment of Xiaoyin granule and acitretin capsule could improve the total effective rate (TER) and cure rate (CR) when compared with acitretin capsule (TER: <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>RR<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>1.15<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI (1.10, 1.21); CR: <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>RR<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>1.8<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, 95% CI (1.62, 2.00)) or Xiaoyin granule (TER: <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>RR<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>1.24<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, 95% CI (1.11, 1.39); CR: <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>RR<\/g:mtext>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>1.75<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, 95% CI (1.54, 1.98)) alone. The combined therapy could decrease the PASI score (mean <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>difference<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mo>\u2212<\/i:mo>\n                        <i:mn>1.45<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, 95% CI (-2.09, -0.80)) and inhibit inflammation (IL-10: mean <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>difference<\/k:mtext>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>1.16<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>, 95% CI (0.94, 1.38); IL-17: mean <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>difference<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mo>\u2212<\/m:mo>\n                        <m:mn>2.06<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, 95% CI (-2.60, -1.51)) in psoriasis vulgaris patients. Conclusions. The combination of Xiaoyin granule and acitretin capsules could be a novel therapeutic strategy in the treatment of psoriasis vulgaris. However, the quality of trials in this study limited the conclusion, and more high-quality RCTs are needed for further evaluation.<\/jats:p>","DOI":"10.1155\/2022\/7360975","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T23:36:13Z","timestamp":1658964973000},"page":"1-14","source":"Crossref","is-referenced-by-count":2,"title":["A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris"],"prefix":"10.1155","volume":"2022","author":[{"given":"Aiai","family":"Geng","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China"},{"name":"Department of Dermatology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi 030024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianli","family":"Pei","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi 030024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-6860","authenticated-orcid":true,"given":"Bo","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184347"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.111299"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5070\/D3195018186"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01827-9"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2360-1"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.156"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.370"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01408.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000455840"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903393732"},{"issue":"47","key":"13","first-page":"4","article-title":"Clinical analysis of Xiaoyin granule combined with acitretin capsule in treating 78 cases of psoriasis","volume":"7","author":"S. 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