{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:08:17Z","timestamp":1775830097508,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFC1309305"],"award-info":[{"award-number":["2017YFC1309305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["KCXFZ20201221173209027"],"award-info":[{"award-number":["KCXFZ20201221173209027"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["SZSM201812063"],"award-info":[{"award-number":["SZSM201812063"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Innovation Commission of Shenzhen","award":["2017YFC1309305"],"award-info":[{"award-number":["2017YFC1309305"]}]},{"name":"Science and Innovation Commission of Shenzhen","award":["KCXFZ20201221173209027"],"award-info":[{"award-number":["KCXFZ20201221173209027"]}]},{"name":"Science and Innovation Commission of Shenzhen","award":["SZSM201812063"],"award-info":[{"award-number":["SZSM201812063"]}]},{"name":"Sanming Medical and Health Projects of Shenzhen","award":["2017YFC1309305"],"award-info":[{"award-number":["2017YFC1309305"]}]},{"name":"Sanming Medical and Health Projects of Shenzhen","award":["KCXFZ20201221173209027"],"award-info":[{"award-number":["KCXFZ20201221173209027"]}]},{"name":"Sanming Medical and Health Projects of Shenzhen","award":["SZSM201812063"],"award-info":[{"award-number":["SZSM201812063"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,6,23]]},"abstract":"<jats:p>Purpose. The study aimed to explore the efficacy and safety of Xinjia Xuanbai Chengqi granules (XJXBCQ) combined with conventional medicine in the treatment of acute exacerbation of chronic pulmonary disease (AECOPD). Patients and Methods. This multicentre, double-blind, parallel, placebo-controlled, randomised clinical trial conducted in China from January 2019 to February 2021 recruited 330 participants who were allocated into three groups. All participants underwent conventional basic treatment with oxygen therapy, antibiotics, and a bronchodilator. Besides, group A received XJXBCQ granules and budesonide suspension for inhalation; group B received XJXBCQ granules and half dosage of budesonide suspension; and group C received budesonide suspension and a placebo. All therapies lasted for 5 days, and participants were followed up for 30 days after discharge. The primary outcomes were efficacy, traditional Chinese medicine (TCM) syndrome score, and clinical symptom score. Secondary outcomes included the blood gas analysis, serum inflammatory markers, adverse events, mortality, theoretical discharge time, actual hospitalisation time, proportion of patients requiring invasive mechanical ventilation, proportion of patients transferred to an intensive care unit (ICU), and readmission rate within 30 days after discharge. Results. XJXBCQ adjunct with conventional treatment could significantly improve the total efficacy (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Meanwhile, group A showed significantly better results than group C in the TCM syndrome score, phlegm score, and Wexner constipation score (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). For modified British medical research council (mMRC), on day 3 (\u22120.17, 95% confidence interval [CI]: \u22120.33\u2013\u22120.01) and day 4 (\u22120.20, 95% CI: \u22120.39\u2013\u22120.02), group A performed statistically better than group C. No significant differences in other secondary outcomes were detected. Conclusion. XJXBCQ is beneficial and safe for AECOPD treatment and could be considered an adjunctive therapy for promoting the relief of clinical symptoms. This trial is registered with ChiCTR1800016915.<\/jats:p>","DOI":"10.1155\/2022\/7366320","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T23:50:18Z","timestamp":1656028218000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["The Efficacy and Safety of Xinjia Xuanbai Chengqi Granules in Acute Exacerbation of COPD: A Multicentre, Randomised, Double-Blind, Controlled Trial"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-7349","authenticated-orcid":true,"given":"Ruihan","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen 518033, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7390-6995","authenticated-orcid":true,"given":"Hongchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-2048","authenticated-orcid":true,"given":"Demin","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0237-5004","authenticated-orcid":true,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Wang Jing Hospital of CACMS, Beijing 100102, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-8106","authenticated-orcid":true,"given":"Qing","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Disease, Xiyuan Hospital of CACMS, Beijing 100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-1998","authenticated-orcid":true,"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen 518033, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-7203","authenticated-orcid":true,"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Disease, Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot 750306, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2250-423X","authenticated-orcid":true,"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine II, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-6621","authenticated-orcid":true,"given":"Zhenhui","family":"Lu","sequence":"additional","affiliation":[{"name":"Respiratory Research Institute of Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-1997","authenticated-orcid":true,"given":"Haibo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Qingdao Haici Medical Group, Qingdao 266033, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6393-0764","authenticated-orcid":true,"given":"Erran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang 110002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-1258","authenticated-orcid":true,"given":"Zhibin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease","author":"Global Initiative for Chronic Obstructive Lung Disease (GOLD)","year":"2019"},{"issue":"10159","key":"2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the global burden of disease study 2017","volume":"392","author":"G. 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