{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:18:36Z","timestamp":1767169116989,"version":"build-2238731810"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hebei Province Medical Science Research Project Planning Fund","award":["20211015"],"award-info":[{"award-number":["20211015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,19]]},"abstract":"<jats:p>Objective. To analyze the application of macrogenomics next-generation sequencing (mNGS) in the detection of postchemotherapy trichomoniasis cases in children with acute leukemia. Methods. To retrospectively analyze the clinical data of 7 patients with acute leukemia combined with trichomoniasis after chemotherapy in the department of hematology and oncology of Hebei Children\u2019s Hospital, and to summarize the characteristics of their postchemotherapy clinical data, diagnostic and therapeutic processes, and outcomes. Results. Among the 7 children, 6 cases had acute lymphoblastic leukemia and 1 case had acute myeloid leukemia. mNGS detected trichoderma infection, including 1 case of pulmonary cerebral type and 6 cases of pulmonary type. After treatment, 1 case died, 2 cases were cured, and 4 cases improved. Conclusion . The clinical manifestations of trichomoniasis after combined chemotherapy in pediatric acute leukemia lack specificity. Early application of the mNGS assay is of great value.<\/jats:p>","DOI":"10.1155\/2022\/7366432","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T16:05:07Z","timestamp":1660925107000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Application Value of Metagenomics Next-Generation Sequencing (mNGS) in Detection of Mucormycosis after Chemotherapy in Childhood Acute Leukemia"],"prefix":"10.1155","volume":"2022","author":[{"given":"Wenzi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Hebei Province Children\u2019s Hospital, Shijiazhuang City 050031, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hebei Province Children\u2019s Hospital Orthopedics Department, Shijiazhuang City 050031, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Hebei Province Children\u2019s Hospital, Shijiazhuang City 050031, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijie","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Hebei Province Children\u2019s Hospital, Shijiazhuang City 050031, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3773-8626","authenticated-orcid":true,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Hebei Province Children\u2019s Hospital, Shijiazhuang City 050031, Hebei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"11","key":"1","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.3324\/haematol.2020.247031","article-title":"Pediatric acute lymphoblastic leukemia","volume":"105","author":"H. Inaba","year":"2020","journal-title":"Haematologica"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/jof4030090","article-title":"Therapy of mucormycosis","volume":"4","author":"N. V. Sipsas","year":"2018","journal-title":"Journal of Fungi"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.07.011"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/jof7080636"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(19)30312-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/jof7080636"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100906"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.751617"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040216"},{"key":"10","first-page":"1","article-title":"Emerging diagnostics for transplant infectious diseases","author":"M. M. Azar","year":"2020","journal-title":"Emerging Transplant Infections: Clinical Challenges and Implications"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1884067"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.07.032"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13755"},{"issue":"2","key":"14","first-page":"2","article-title":"Is need chemotherapy titration during acute myeloid leukemia treatment","volume":"131","author":"B. Abdolkarimi","year":"2021","journal-title":"Journal of Oncology Research Reviews and Reports"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.06.022"},{"issue":"9","key":"16","article-title":"A retrospective epidemiological analysis of fungal infections of skin and soft tissue in a health care setup in Delhi, India","volume":"12","author":"H. Butta","year":"2018","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3126\/jpn.v9i1.23377"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13123029"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-021-01810-4"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280670"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-022-00790-4"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164068"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpo.2021.100288"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06741-5"}],"updated-by":[{"DOI":"10.1155\/2023\/9764181","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"record-id":"48566"},{"DOI":"10.1155\/2023\/9764181","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7366432.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7366432.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7366432.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T16:05:16Z","timestamp":1660925116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/7366432\/"}},"subtitle":[],"editor":[{"given":"Shuli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":24,"alternative-id":["7366432","7366432"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7366432","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,19]]}}}