{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:41:59Z","timestamp":1771994519023,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Funds for the Central Government to Guide Local Science and Technology Development","award":["QKZYD(2019)4008"],"award-info":[{"award-number":["QKZYD(2019)4008"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To explore the function and mechanism of Sirt\u20101 in fluorine\u2010induced liver injury. <jats:italic>Method<\/jats:italic>. Fluorosis rats were first established. The fluorine content, pathological structure, collagen fibers, and fibrosis in liver tissues were tested through the fluoride ion selective electrode method, H&amp;E, Masson, and Sirius red staining; alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin 18 (IL\u201018), and tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) levels in rat serum were also analyzed using ELISA kits. Then, the fluorosis cell model was built, which was also alleviated with NaF, Sirt\u20101 siRNAs, or endoplasmic reticulum stress (ERS) alleviator (4\u2010PBA). CCK\u20108 also assessed cell proliferation; RT\u2010qPCR or Western blots detect sirtuin\u20101 (Sirt\u20101), protein kinase R\u2010 (PKR\u2010) like endoplasmic reticulum kinase (PERK), and endoplasmic reticulum stress (ERS) and apoptosis\u2010related protein levels in liver tissue. <jats:italic>Results<\/jats:italic>. Our results uncovered that fluorine exposure could aggravate the pathological damage and fibrosis of rat liver tissues and increase indicators related to liver injury. And fluoride exposure also could downregulate Sirt\u20101 and upregulate ERS\u2010related proteins (PERK, 78\u2010kD glucose\u2010regulated protein (GRP\u201078), and activating transcription factor 6 (ATF6)) and apoptosis\u2010related protein (caspase\u20103 and C\/EBP\u2010homologous protein (CHOP)) in rat liver tissues. Besides, we proved that fluoride exposure could suppress proliferation and enhances ERS and apoptotic pathways in AML12 cells by downregulating Sirt\u20101. Moreover, we revealed that ERS alleviator (4\u2010PBA) could induce proliferation and prevent ERS and apoptosis in fluorine\u2010exposed AML12 cells. <jats:italic>Conclusions<\/jats:italic>. We suggested that fluorine exposure can induce hepatocyte ERS and apoptosis through downregulation of Sirt\u20101.<\/jats:p>","DOI":"10.1155\/2022\/7380324","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T21:50:05Z","timestamp":1661118605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["[Retracted] Fluoride Exposure Suppresses Proliferation and Enhances Endoplasmic Reticulum Stress and Apoptosis Pathways in Hepatocytes by Downregulating Sirtuin\u20101"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9653-4423","authenticated-orcid":false,"given":"Yanlong","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7460-972X","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9040-5383","authenticated-orcid":false,"given":"Wenfeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-1460","authenticated-orcid":false,"given":"Zhizhong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,21]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109300"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c02745"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2017.11.003"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01263"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14185"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0871-4"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4625-42.5.1"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.09.019"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02641-1"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2019-0362"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.09.005"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.3290\/j.cjdr.b1530481"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-0602-4_8"},{"key":"e_1_2_10_14_2","first-page":"9990","article-title":"Endoplasmic reticulum stress-mediated apoptosis signal pathway is involved in sepsis-induced liver injury","volume":"10","author":"Qian W. 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