{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:04:32Z","timestamp":1773878672584,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Investigating the effect of ondansetron on the efficacy of tramadol in patients undergoing laparoscopic cholecystectomy. <jats:italic>Methods<\/jats:italic>. Sixty American Society of Anesthesiologists (ASA) I\u2010II patients over the age of 18 who underwent laparoscopic cholecystectomy were included in this study. All patients were given 1\u2009mg\/kg tramadol intravenously (iv) during the intraoperative period. Patients were randomly assigned to receive either 4\u2009mg ondansetron (Group O) or 2\u2009mL saline (Group S). Postoperative tramadol consumption, pain score (NRS), intensity of nausea (NRS), presence of vomiting, consumption of rescue analgesics and antiemetics, and patient satisfaction were recorded. <jats:italic>Results<\/jats:italic>. A total of 60 patients were enrolled in the study; five patients were excluded due to deviation from the protocol. Data from 55 patients (Group O: 28 patients, Group S: 27 patients) were evaluated in the study. No differences between the two groups were detected for postoperative consumption of tramadol, pain score (NRS), intensity of nausea (NRS), presence of vomiting, consumption of rescue analgesics and antiemetics, and patient satisfaction. <jats:italic>Conclusions<\/jats:italic>. The results showed that coadministration of tramadol and ondansetron did not change tramadol consumption during the postoperative 24 hours after laparoscopic cholecystectomy. Clinical trial registration number is as follows: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04745273\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04745273<\/jats:ext-link>\u201401\/31\/2021.<\/jats:p>","DOI":"10.1155\/2022\/7387600","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T20:35:12Z","timestamp":1646771712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of Ondansetron on the Analgesic Efficacy of Tramadol in Patients Undergoing Laparoscopic Cholecystectomy"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-9922","authenticated-orcid":false,"given":"Sevgi","family":"Bilgen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-5323","authenticated-orcid":false,"given":"Dilek","family":"Erdo\u011fan Ari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2628-5553","authenticated-orcid":false,"given":"Emel","family":"\u00d6zveri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12948"},{"key":"e_1_2_10_2_2","first-page":"395","article-title":"Tramadol, pharmacology, side effects, and Serotonin syndrome: a review","volume":"18","author":"Beakley B. 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