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However, continental Africans are yet to be adequately represented in such studies despite the importance of genetic factors in understanding Africa\u2019s response to the pandemic. We describe the development of a research resource for coronavirus host genomics studies in South Africa known as COVIGen-SA\u2014a multicollaborator strategic partnership designed to provide harmonised demographic, clinical, and genetic information specific to Black South Africans with COVID-19. Over 2,000 participants have been recruited to date. Preliminary results on 1,354 SARS-CoV-2 positive participants from four participating studies showed that 64.7% were female, 333 had severe disease, and 329 were people living with HIV. Through this resource, we aim to provide insights into host genetic factors relevant to African-ancestry populations, using both genome-wide association testing and targeted sequencing of important genomic loci. This project will promote and enhance partnerships, build skills, and develop resources needed to address the COVID-19 burden and associated risk factors in South African communities.<\/jats:p>","DOI":"10.1155\/2022\/7405349","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T15:35:46Z","timestamp":1665070546000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["Coronavirus Host Genomics Study: South Africa (COVIGen-SA)"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-1566","authenticated-orcid":true,"given":"Andrew K.","family":"May","sequence":"first","affiliation":[{"name":"Sydney Brenner Institute for Molecular Bioscience (SBIMB), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-2170","authenticated-orcid":true,"given":"Heather","family":"Seymour","sequence":"additional","affiliation":[{"name":"Sydney Brenner Institute for Molecular Bioscience (SBIMB), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-5754","authenticated-orcid":true,"given":"Harriet","family":"Etheredge","sequence":"additional","affiliation":[{"name":"Wits Donald Gordon Medical Centre, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Steve Biko Centre for Bioethics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3635-6346","authenticated-orcid":true,"given":"Heather","family":"Maher","sequence":"additional","affiliation":[{"name":"Wits Donald Gordon Medical Centre, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-878X","authenticated-orcid":true,"given":"Marta C.","family":"Nunes","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines and Infectious Diseases Analytics (VIDA) Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-0636","authenticated-orcid":true,"given":"Shabir A.","family":"Madhi","sequence":"additional","affiliation":[{"name":"South African Medical Research Council, Vaccines and Infectious Diseases Analytics (VIDA) Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Science and Technology, National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2707-1533","authenticated-orcid":true,"given":"Simiso M.","family":"Sokhela","sequence":"additional","affiliation":[{"name":"Ezintsha, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-732X","authenticated-orcid":true,"given":"W. 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