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From this new perspective, we first examine SESTRIN2 structure-function relationships; then, we describe how SESTRIN2 expression is regulated under oxidative stress conditions, emphasizing SESTRIN2\u2019s antioxidant mechanism via multiple signal transductions; and finally, we discuss SESTRIN2\u2019s role in a variety of oxidative stress-related cardiac diseases, including age-related heart disease, diabetic cardiomyopathy, ischemia-reperfusion myocardial injury, septic cardiomyopathy, and chronic cardiac insufficiency. The goal of this review is to identify the SESTRIN2 protein as a potential biomarker and new therapy target for oxidative stress-related cardiac diseases.<\/jats:p>","DOI":"10.1155\/2022\/7439878","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T18:50:08Z","timestamp":1659120608000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Oxidative Stress-Induced Protein of SESTRIN2 in Cardioprotection Effect"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0974-4762","authenticated-orcid":true,"given":"Huang","family":"Rongjin","sequence":"first","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University\/Department of Emergency, Fujian Provincial Hospital\/Fujian Key Laboratory of Emergency Medicine, Fujian Provincial Hospital\/Fujian Provincial Institute of Emergency Medicine\/Fujian Emergency Medical Center, Fuzhou 350001, 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