{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:18:21Z","timestamp":1767169101618,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":228,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016108","name":"Shanghai Baoshan Science and Technology Commission","doi-asserted-by":"publisher","award":["21-E-59"],"award-info":[{"award-number":["21-E-59"]}],"id":[{"id":"10.13039\/501100016108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    The effect of the TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    pathway\u2010based pituitary tumor of rats on the GH3 cell line after intervention with different concentrations of troglitazone (TGZ) is explored. The CH3 cell line of 24 clean male SD rats with pituitary adenoma is selected. The cells are divided into a blank contrast set and an experimental set. The experimental set is divided into different TGZ concentration sets, including 1\u2009\u00d7\u200910\n                    <jats:sup>\u22123<\/jats:sup>\n                    TGZ set, 1\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    TGZ set, and 1\u2009\u00d7\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    TGZ set. The cell proliferation is detected by the CCK\u20108 method, the protein expressions of CD147, TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1, and MMP\u20109 are detected by the western blot method, and the relative mRNA expressions of CD147, TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1, and MMP\u20109 are detected by the qRT\u2010PCR method. The expression levels of CD147, TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1, and MMP\u20109 in CH3 cells of pituitary adenoma rats are notoriously lower, while the expression of CD147, TGF\u201031, and MMP\u20109 could be reduced by TGZ acting on the GH3 cell line. The specific mechanism of action of this effect on the invasive ability of GH3 cell lines is multifaceted, suggesting that peroxisome proliferator activator\u2010receptor (PPAR\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    ) agonists have good clinical application prospects in tumor therapy and can provide new targets and approaches for tumor drug therapy.\n                  <\/jats:p>","DOI":"10.1155\/2022\/7445042","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T19:35:28Z","timestamp":1660764928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["[Retracted] Exploration of the Effects of TGF\u2010\u03b2 Pathway\u2010Based Pituitary Tumor of Rats on GH3 Cell Line after Intervention with Different Concentrations of TGZ"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jiafeng","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiujuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-4931","authenticated-orcid":false,"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-020-01028-0"},{"key":"e_1_2_11_2_2","first-page":"355","article-title":"A Effects of octreotide on hallmarks of autophagy and on parameters concerningto cell viability and metabolic activity in rat pituitary tumor cells","volume":"33","author":"Tulipano G.","year":"2019","journal-title":"Endocrine Abstracts"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-4889(97)00053-0"},{"key":"e_1_2_11_4_2","first-page":"81","article-title":"Effects of different concentrations of dexamethasone on pulmonary histology in rats with chronic asthma","volume":"26","author":"Ren F.","year":"2020","journal-title":"Journal of Hainan Medical University"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2019040"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110868"},{"key":"e_1_2_11_7_2","unstructured":"MahmoudH. 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