{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:40:21Z","timestamp":1788025221601,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":214,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. In the early stages of the COVID\u201019 pandemic, elevated inflammatory cytokine levels, particularly interleukin\u20106 (IL\u20106), were detected in patients with cytokine storm (CS). <jats:italic>Aims<\/jats:italic>. This study aimed to investigate levels, diagnostic usefulness, and optimal cutoff values of monocyte, eosinophil, neutrophil\u2010lymphocyte ratio (NLR), and platelet\u2010lymphocyte ratio (PLR) in CS of patients with COVID\u201019 and also to identify risk factors for mortality. <jats:italic>Methods<\/jats:italic>. Seventy\u2010six patients with COVID\u201019 who developed CS and randomly chosen 150 COVID\u201019 patients who had no CS during their stay in the hospital were included in the study. <jats:italic>Results<\/jats:italic>. Lymphocytes and eosinophil levels remained lower in the CS group. Patients with low lymphocyte levels had a higher risk for mortality (OR: 1.92). Neutrophil, D\u2010dimer, ferritin, IL\u20106, NLR, and PLR were higher in the CS group. High levels of neutrophil, ferritin, D\u2010dimer, and NLR and a history of coronary artery disease (CAD) and diabetes mellitus (DM) were identified as independent risk factors for mortality. <jats:italic>Conclusion<\/jats:italic>. In the light of the obtained results, COVID\u201019 patients with a decrease in lymphocyte levels and an increase in NLR and D\u2010dimer levels and a history of CAD and DM have a higher risk of cytokine storm and mortality.<\/jats:p>","DOI":"10.1155\/2022\/7450739","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T10:50:07Z","timestamp":1659523807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Eosinophil Levels, Neutrophil\u2010Lymphocyte Ratio, and Platelet\u2010Lymphocyte Ratio in the Cytokine Storm Period of Patients with COVID\u201019"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-7331","authenticated-orcid":false,"given":"Ibrahim","family":"Koc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4996-3014","authenticated-orcid":false,"given":"Sevda","family":"Unalli Ozmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03006-2020"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.18502\/ijaai.v18i1.628"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14970"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180522085716"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2108482"},{"key":"e_1_2_9_6_2","unstructured":"BektasS. 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