{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:48:11Z","timestamp":1781815691069,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["P2020042"],"award-info":[{"award-number":["P2020042"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2020ZD03"],"award-info":[{"award-number":["2020ZD03"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2021MS068"],"award-info":[{"award-number":["2021MS068"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational Intelligence and Neuroscience"],"published-print":{"date-parts":[[2022,4,7]]},"abstract":"<jats:p>Background. Chloasma is a common skin pigment disorder. Treatment of chloasma has been challenging, often unsatisfactory, and difficult to avoid recurrence. PRP is a new treatment for chloasma, but there is no consensus on its use. Lingyun Zhao\u2019s team recently reported a systematic evaluation and meta-analysis of the efficacy and safety of PRP in the treatment of chloasma, which is consistent with our ideas, but we will elaborate on the application of PRP in chloasma from a deeper and more comprehensive perspective. Before we started this study, we had registered with Prospero as CRD42021233721. Methods. The authors searched the public medical network, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ScienceDirect, Scopus, and Science Network. The clinical trials registry ClinicalTrials.gov databases were searched for relevant publications to June 2021. The results showed the area and severity of chloasma (MASI) or revised MASI (mMASI) score. Results. Three RCTs, one nonrandomized controlled study, and four were prospective before and after self-controlled studies met the inclusive criteria. Intradermal PRP injections significantly improved chloasma as indicated by the significant decrease MASI (average balance -6.71, 95% CI -8.99 to -4.33) and mMASI scores (average balance -2.94, 95% CI -4.81 to -1.07). The adverse reactions were mild, and there were no significant long-term adverse events. Conclusive. The data can reflect the effectiveness and safety of PRP therapy for chloasma. RCTs are needed to determine effective treatment parameters, and long-term follow-up should be included to better clarify the efficacy and side effects of PRP in treating chloasma.<\/jats:p>","DOI":"10.1155\/2022\/7487452","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T22:05:07Z","timestamp":1649369107000},"page":"1-14","source":"Crossref","is-referenced-by-count":13,"title":["Application of PRP in Chloasma: A Meta-Analysis and Systematic Review"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-5780","authenticated-orcid":true,"given":"Tinghan","family":"Deng","sequence":"first","affiliation":[{"name":"Clinical Research on Skin Diseases School of Clinical Medicine, Chengdu University of TCM, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-083X","authenticated-orcid":true,"given":"Fengrui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-6139","authenticated-orcid":true,"given":"Shanshan","family":"Guo","sequence":"additional","affiliation":[{"name":"Clinical Research on Skin Diseases School of Clinical Medicine, Chengdu University of TCM, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-713X","authenticated-orcid":true,"given":"Hongbin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Dermatology of Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8447-7188","authenticated-orcid":true,"given":"Jingping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"5","key":"1","first-page":"502","article-title":"Comparing the efficacy of patelet-rich plasma (PRP) versus tranexamic acid (4mg\/mL) as intradermal treatments of chloasma","volume":"30","author":"M. 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Merch\u00e1n","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2019.1668016"},{"key":"9","first-page":"1","article-title":"Comparative study between topical tranexamic acid alone versus its combination with autologous platelet rich plasma for treatment of melasma","author":"M. M. Gamea","year":"2020","journal-title":"Journal of Dermatological Treatment"},{"issue":"8","key":"10","first-page":"28","article-title":"Progress in the use of platelet-rich plasma in aesthetic and medical dermatology","volume":"13","author":"M. 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Tuknayat","year":"2020","journal-title":"Journal of the Dermatology Nurses\u2019 Association"},{"key":"18","first-page":"e15008","article-title":"Study of autologous platelet-rich-plasma versus its combination with intense pulsed light in treatment of Chloasma","author":"S. Adel","year":"2021","journal-title":"Dermatologic Therapy"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1781755"},{"issue":"3","key":"20","first-page":"348","article-title":"Efficacy of platelet-rich plasma in the treatment of Chloasma: a pilot study","volume":"28","author":"F. Faiz","year":"2018","journal-title":"Journal of Pakistan Association of Dermatologists"},{"issue":"4","key":"21","article-title":"Chloasma: a clinico-epidemiological study of 312 cases","volume":"56","author":"A. 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