{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:13:36Z","timestamp":1767168816039,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,4,18]]},"abstract":"<jats:p>One of the most important surgical approaches for restoring cutaneous abnormalities caused by tumor resection is the insertion of a skin flap. Flap transplantation has been used to cover and fill different deficiencies after tumor removal. However, distal necrosis is among the most prevalent postsurgical consequences for skin flaps, particularly when treating large regions. Blood circulation failure causes flap necrosis, which may lead to serious problems, particularly in patients undergoing body cavity reconstruction following tumor excision. ADSCs (adipose-derived stem cells) are a kind of stem cell separated from the adipose tissue that has multilineage differentiation, simple availability, high proliferation capability, and self-renewal capabilities. This paper uses human adipose-derived stem cell (ADSC) therapy for skin flap transplantation in skin malignant tumor resection. ADSC-based therapy is an applicable technique for assisting flap transplantation. The isolation of ADSC is performed using different trypsin concentrations, and then, the population doubling time is determined. The isolated ADSCs are differentiated and then employed for the skin flap model. The performance of the suggested method is analyzed using various assays. The usage of adipose-derived stem cells to boost the vitality of the skin flaps proved successful.<\/jats:p>","DOI":"10.1155\/2022\/7510330","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T12:20:08Z","timestamp":1650284408000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Application of Free Skin Flap Transplantation in Skin Malignant Tumor Resection"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-6963","authenticated-orcid":true,"given":"Yue","family":"Zhou","sequence":"first","affiliation":[{"name":"Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-3571","authenticated-orcid":true,"given":"Weili","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-9022","authenticated-orcid":true,"given":"Jue","family":"Hou","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-9364","authenticated-orcid":true,"given":"Chunsheng","family":"Hou","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-3453","authenticated-orcid":true,"given":"Jufang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Hangzhou Hospital of Nanjing Medical University, Nanjing, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"23","key":"1","first-page":"8","article-title":"Evaluation of the clinical efficacy of partial skin flaps in repairing facial soft tissue defects","volume":"5","author":"Y. 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